Gene
selenoh
- ID
- ZDB-GENE-030411-2
- Name
- selenoprotein H
- Symbol
- selenoh Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Acts upstream of or within several processes, including cell redox homeostasis; liver development; and pancreas development. Predicted to be active in Golgi apparatus. Is expressed in several structures, including digestive system; immature eye; nervous system; neural tube; and pectoral fin. Orthologous to human SELENOH (selenoprotein H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb697 (22 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2737Tg | Transgenic insertion | 3' UTR | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Selenoprotein, Rdx-type | Selenoprotein SelWTH-like | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1PAE4 | InterPro | 127 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
selenoh-201
(1)
|
Ensembl | 1,335 nt | ||
| mRNA |
selenoh-202
(1)
|
Ensembl | 867 nt | ||
| mRNA |
selenoh-203
(1)
|
Ensembl | 1,704 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-150E8 | ZFIN Curated Data | |
| Encodes | EST | cb697 | Thisse et al., 2001 | |
| Has Artifact | EST | fa11g07 | ||
| Has Artifact | EST | fb23d03 | ZFIN Curated Data | |
| Has Artifact | EST | IMAGE:6893123 | Thisse et al., 2004 | |
| Has Artifact | cDNA | MGC:55775 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178133 (1) | 827 nt | ||
| Genomic | GenBank:BX469901 (2) | 180553 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAE4 (1) | 127 aa |
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Zada, D., Bronshtein, I., Lerer-Goldshtein, T., Garini, Y., Appelbaum, L. (2019) Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons. Nature communications. 10:895
- Cox, A.G., Tsomides, A., Kim, A.J., Saunders, D., Hwang, K.L., Evason, K.J., Heidel, J., Brown, K.K., Yuan, M., Lien, E.C., Lee, B.C., Nissim, S., Dickinson, B., Chhangawala, S., Chang, C.J., Asara, J.M., Houvras, Y., Gladyshev, V.N., Goessling, W. (2016) Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 113(38):E5562-71
- Penglase, S., Hamre, K., Ellingsen, S. (2014) Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury. Free radical biology & medicine. 75:95-104
- Mariotti, M., Ridge, P.G., Zhang, Y., Lobanov, A.V., Pringle, T.H., Guigo, R., Hatfield, D.L., Gladyshev, V.N. (2012) Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes. PLoS One. 7(3):e33066
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene expression patterns : GEP. 3(4):525-532
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