Gene
selenon
- ID
- ZDB-GENE-030327-7
- Name
- selenoprotein N
- Symbol
- selenon Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable oxidoreductase activity. Involved in muscle cell development; muscle tissue development; and regulation of ryanodine-sensitive calcium-release channel activity. Acts upstream of or within skeletal muscle fiber development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including anterior axial hypoblast; mesoderm; nervous system; tail bud; and trunk. Human ortholog(s) of this gene implicated in rigid spine muscular dystrophy 1. Orthologous to human SELENON (selenoprotein N).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb686 (26 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-selenon | N/A | Deniziak et al., 2007 |
| MO2-selenon | N/A | Deniziak et al., 2007 |
| MO3-selenon | N/A | Deniziak et al., 2007 |
| MO4-selenon | N/A | Deniziak et al., 2007 |
| MO5-selenon | N/A | Jurynec et al., 2008 |
| MO6-selenon | N/A | Jurynec et al., 2008 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| rigid spine muscular dystrophy 1 | Alliance | Congenital myopathy 3 with rigid spine | 602771 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:Q3Y4E2 | InterPro | 557 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-15D5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-247C16 | ||
| Encodes | EST | cb686 | Thisse et al., 2001 | |
| Encodes | EST | fb06g01 | ||
| Encodes | EST | fb73d02 | ||
| Encodes | EST | fv41b08 | ||
| Encodes | cDNA | MGC:101091 | ||
| Encodes | cDNA | MGC:174730 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004294 (1) | 2896 nt | ||
| Genomic | GenBank:CR626962 (2) | 117015 nt | ||
| Polypeptide | UniProtKB:Q3Y4E2 (1) | 557 aa |
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Penglase, S., Hamre, K., Ellingsen, S. (2014) Selenium prevents downregulation of antioxidant selenoprotein genes by methylmercury. Free radical biology & medicine. 75:95-104
- Wang, K., Ma, J., He, M., Gao, G., Xu, H., Sang, J., Wang, Y., Zhao, B., and Cui, D. (2013) Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos. Theranostics. 3(4):258-266
- Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852
- Mariotti, M., Ridge, P.G., Zhang, Y., Lobanov, A.V., Pringle, T.H., Guigo, R., Hatfield, D.L., Gladyshev, V.N. (2012) Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes. PLoS One. 7(3):e33066
- Jurynec, M.J., Xia, R., Mackrill, J.J., Gunther, D., Crawford, T., Flanigan, K.M., Abramson, J.J., Howard, M.T., and Grunwald, D.J. (2008) Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proceedings of the National Academy of Sciences of the United States of America. 105(34):12485-12490
- Deniziak, M., Thisse, C., Rederstorff, M., Hindelang, C., Thisse, B., and Lescure, A. (2007) Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Experimental cell research. 313(1):156-167
- Steffen, L.S., Guyon, J.R., Vogel, E.D., Beltre, R., Pusack, T.J., Zhou, Y., Zon, L.I., and Kunkel, L.M. (2007) Zebrafish orthologs of human muscular dystrophy genes. BMC Genomics. 8(1):79
- Eastman, S.D., Chen, T.H., Falk, M.M., Mendelson, T.C., and Iovine, M.K. (2006) Phylogenetic analysis of three complete gap junction gene families reveals lineage-specific duplications and highly supported gene classes. Genomics. 87(2):265-274
- Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H. (2006) Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Trends in genetics : TIG. 22(4):203-210
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