ZFIN ID: ZDB-GENE-030326-6
Gene Name: snail family zinc finger 2
Gene Symbol: snai2    Nomenclature History

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Previous Names: cb147 (1), cb355 (1), id:ibd5003, sb:cb355, sb:cb569, slug (1), wu:fb83e12, wu:fd19g11, zgc:92564

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; neural crest; and splanchnocranium. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2).
Genome Resources: Alliance (1),  Gene:494038 (1),  Ensembl(GRCz11):ENSDARG00000040046 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24539 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sd57 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-snai2 1
    CRISPR2-snai2 1
    CRISPR3-snai2 1
    MO1-snai2 N/A 3
    MO2-snai2 N/A 1
    DISEASE ASSOCIATED WITH snai2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    piebaldism Alliance Piebaldism 172800
    Waardenburg syndrome type 2D Alliance Waardenburg syndrome, type 2D 608890
    DISEASE ASSOCIATED WITH snai2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA snai2-201 (1)    Ensembl 2992
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM snai2 No data available
    MARKER RELATIONSHIPS
    snai2 Contained in: [BAC] CH211-106J11 (1)
    snai2 Encodes: [EST] cb147 (1) (order this), cb355 (1) (order this), cb569 (1) (order this), fb83e12, fd19g11 (1), ibd5003
    [cDNA] MGC:92564 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001008581 (1) 3005 nt
    Genomic GenBank:CR354603 (1) 159582 nt
    Select Tool
    Polypeptide UniProtKB:Q5PQY5 (1) 257 aa
    Sequence Information (all 20)
    ORTHOLOGY for snai2 ( Chr: 24 )
    CITATIONS (54)