Gene

dlst

ID

ZDB-GENE-030326-1

Name

dihydrolipoamide S-succinyltransferase

Symbol

dlst Nomenclature History

Previous Names

cb60 (1)
schneckentempo (1)
wu:fc39d01

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb60 (31 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dlst Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pheochromocytoma/paraganglioma syndrome 7	618475

Associated With dlst Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR003016	2-oxo acid dehydrogenase, lipoyl-binding site
Domain	IPR000089	Biotin/lipoyl attachment
Domain	IPR001078	2-oxoacid dehydrogenase acyltransferase, catalytic domain
Family	IPR006255	Dihydrolipoamide succinyltransferase
Family	IPR050537	2-oxoacid dehydrogenase
Homologous_superfamily	IPR011053	Single hybrid motif
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily

Domain Details Per Protein

Protein	Length	2-oxoacid dehydrogenase	2-oxoacid dehydrogenase acyltransferase, catalytic domain	2-oxo acid dehydrogenase, lipoyl-binding site	Biotin/lipoyl attachment	Chloramphenicol acetyltransferase-like domain superfamily	Dihydrolipoamide succinyltransferase	Single hybrid motif
UniProtKB:Q7ZVL3 InterPro	458

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dlst-201 (1) Ensembl	Ensembl	1,889 nt	Select Tool
ncRNA	dlst-002 (1) Ensembl	Ensembl	725 nt	Select Tool
ncRNA	dlst-003 (1) Ensembl	Ensembl	764 nt	Select Tool
ncRNA	dlst-004 (1) Ensembl	Ensembl	706 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations