Gene

dlst

ID
ZDB-GENE-030326-1
Name
dihydrolipoamide S-succinyltransferase
Symbol
dlst Nomenclature History
Previous Names
  • cb60 (1)
  • schneckentempo (1)
  • wu:fc39d01
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
hi1903cTgTransgenic insertionIntron 1UnknownDNA
la027887TgTransgenic insertionUnknownUnknownDNA
sa17039Allele with one point mutationUnknownSplice SiteENU
t21498Allele with one point mutationDonor Splice Site of Intron 5Splice Site, Frameshift, Premature StopENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-dlstN/AKeßler et al., 2015
MO2-dlstN/AKeßler et al., 2015
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Human Disease
Associated With dlst Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pheochromocytoma/paraganglioma syndrome 7 618475
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Associated With dlst Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site
Domain IPR000089 Biotin/lipoyl attachment
Domain IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
Family IPR006255 Dihydrolipoamide succinyltransferase
Family IPR050537 2-oxoacid dehydrogenase
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Domain Details Per Protein
Protein Length 2-oxoacid dehydrogenase 2-oxoacid dehydrogenase acyltransferase, catalytic domain 2-oxo acid dehydrogenase, lipoyl-binding site Biotin/lipoyl attachment Chloramphenicol acetyltransferase-like domain superfamily Dihydrolipoamide succinyltransferase Single hybrid motif
UniProtKB:Q7ZVL3 458
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 17
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA dlst-201 (1) Ensembl 1,889 nt
ncRNA dlst-002 (1) Ensembl 725 nt
ncRNA dlst-003 (1) Ensembl 764 nt
ncRNA dlst-004 (1) Ensembl 706 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-173A9ZFIN Curated Data
ContainsSNPrs3728885
    ContainsSNPrs3728886
      ContainsSNPrs3728887
        EncodesESTcb60Thisse et al., 2001
        EncodesESTfc39d01ZFIN Curated Data
        EncodescDNAMGC:55935ZFIN Curated Data
        EncodescDNAMGC:77238ZFIN Curated Data
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        Sequences
        Orthology
        Comparative Orthology
        Alliance
        Gene Tree
        Ensembl
        Species Symbol Chromosome Accession # Evidence
        HumanDLST14
        Amino acid sequence comparison (4)
        Conserved genome location (synteny) (1)
        MouseDlst12
        Conserved genome location (synteny) (1)
        Amino acid sequence comparison (1)
        Citations
        1 - 10 of 14
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