Gene
dlst
- ID
- ZDB-GENE-030326-1
- Name
- dihydrolipoamide S-succinyltransferase
- Symbol
- dlst Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have dihydrolipoyllysine-residue succinyltransferase activity. Involved in several processes, including ATP biosynthetic process; heart contraction; and mitochondrion morphogenesis. Predicted to localize to oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Is expressed in several structures, including immature eye; musculature system; nervous system; neural plate; and segmental plate. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb60 (31 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
hi1903cTg | Transgenic insertion | Intron 1 | Unknown | DNA | |
la027887Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa17039 | Allele with one point mutation | Unknown | Splice Site | ENU | |
t21498 | Allele with one point mutation | Donor Splice Site of Intron 5 | Splice Site, Frameshift, Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-dlst | N/A | Keßler et al., 2015 |
MO2-dlst | N/A | Keßler et al., 2015 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Pheochromocytoma/paraganglioma syndrome 7 | 618475 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR003016 | 2-oxo acid dehydrogenase, lipoyl-binding site |
Domain | IPR000089 | Biotin/lipoyl attachment |
Domain | IPR001078 | 2-oxoacid dehydrogenase acyltransferase, catalytic domain |
Family | IPR006255 | Dihydrolipoamide succinyltransferase |
Family | IPR050537 | 2-oxoacid dehydrogenase |
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Domain Details Per Protein
Protein | Length | 2-oxoacid dehydrogenase | 2-oxoacid dehydrogenase acyltransferase, catalytic domain | 2-oxo acid dehydrogenase, lipoyl-binding site | Biotin/lipoyl attachment | Chloramphenicol acetyltransferase-like domain superfamily | Dihydrolipoamide succinyltransferase | Single hybrid motif |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q7ZVL3
|
458 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-173A9 | ZFIN Curated Data | |
Contains | SNP | rs3728885 | ||
Contains | SNP | rs3728886 | ||
Contains | SNP | rs3728887 | ||
Encodes | EST | cb60 | Thisse et al., 2001 | |
Encodes | EST | fc39d01 | ZFIN Curated Data | |
Encodes | cDNA | MGC:55935 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77238 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201487 (1) | 1898 nt | ||
Genomic | GenBank:BX927356 (1) | 204195 nt | ||
Polypeptide | UniProtKB:Q7ZVL3 (1) | 458 aa |
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Anderson, N.M., Qin, X., Finan, J.M., Lam, A., Athoe, J., Missiaen, R., Skuli, N., Kennedy, A., Saini, A.S., Tao, T., Zhu, S., Nissim, I., Look, A.T., Qing, G., Simon, M.C., Feng, H. (2021) Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer research. 81(17):4417-4430
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Anderson, N.M., Li, D., Peng, H.L., Laroche, F.J., Mansour, M.R., Gjini, E., Aioub, M., Helman, D.J., Roderick, J.E., Cheng, T., Harrold, I., Samaha, Y., Meng, L., Amsterdam, A., Neuberg, D.S., Denton, T.T., Sanda, T., Kelliher, M.A., Singh, A., Look, A.T., Feng, H. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 30(6):1365-74
- Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69
- Keßler, M., Berger, I.M., Just, S., Rottbauer, W. (2015) Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. Basic Research in Cardiology. 110:468
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Tiefenbach, J., Moll, P.R., Nelson, M.R., Hu, C., Baev, L., Kislinger, T., and Krause, H.M. (2010) A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. PLoS One. 5(3):e9797
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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