Gene
prkaa1
- ID
- ZDB-GENE-030325-1
- Name
- protein kinase, AMP-activated, alpha 1 catalytic subunit
- Symbol
- prkaa1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of hh target transcription factor activity and regulation of lipid metabolic process. Predicted to be located in plasma membrane bounded cell projection. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including axis; digestive system; mesoderm; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; and colon cancer. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb116 (14 images)
- cb130 (29 images)
- IMAGE:7154392 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR028797 | PRKAA1, UBA-like autoinhibitory domain |
| Domain | IPR032270 | AMPK, C-terminal adenylate sensor domain |
| Domain | IPR039137 | 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal |
| Domain | IPR049020 | PRKAA1/2, autoinhibitory domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Additional Resources | Length | 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal | AMPK, C-terminal adenylate sensor domain | KA1 domain/Ssp2, C-terminal | PRKAA1/2, autoinhibitory domain | PRKAA1, UBA-like autoinhibitory domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A5WUM0 | InterPro | 573 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkaa1-201
(1)
|
Ensembl | 3,939 nt |
Interactions and Pathways
No data available
Plasmids
No data available