Gene
ftr82
- ID
- ZDB-GENE-030219-207
- Name
- finTRIM family, member 82
- Symbol
- ftr82 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable zinc ion binding activity. Acts upstream of or within vasculature development. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; digestive system; head mesenchyme; mesoderm; and pleuroperitoneal region. Orthologous to human TRIM29 (tripartite motif containing 29) and TRIM65 (tripartite motif containing 65).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb579 (35 images)
- IMAGE:7166053 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Chang et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ftr82 | (2) | |
| MO1-ftr82 | N/A | Chang et al., 2017 |
| MO2-ftr82 | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017907 | Zinc finger, RING-type, conserved site |
| Domain | IPR000315 | B-box-type zinc finger |
| Domain | IPR001841 | Zinc finger, RING-type |
| Domain | IPR001870 | B30.2/SPRY domain |
| Domain | IPR003877 | SPRY domain |
| Domain | IPR003879 | Butyrophylin-like, SPRY domain |
| Domain | IPR006574 | SPRY-associated |
| Family | IPR051051 | E3 ubiquitin-protein ligase TRIM/RNF |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR043136 | B30.2/SPRY domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | B30.2/SPRY domain | B30.2/SPRY domain superfamily | B-box-type zinc finger | Butyrophylin-like, SPRY domain | Concanavalin A-like lectin/glucanase domain superfamily | E3 ubiquitin-protein ligase TRIM/RNF | SPRY-associated | SPRY domain | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, RING-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q08CC1 | InterPro | 573 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-117M20 | ZFIN Curated Data | |
| Encodes | EST | cb579 | Thisse et al., 2001 | |
| Encodes | EST | fb99c05 | ZFIN Curated Data | |
| Encodes | EST | ibd1340 | ||
| Encodes | EST | IMAGE:7166053 | Thisse et al., 2004 | |
| Encodes | STS | chunp30235 | ||
| Encodes | cDNA | MGC:153276 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001075103 (1) | 2260 nt | ||
| Genomic | GenBank:BX294376 (1) | 178400 nt | ||
| Polypeptide | UniProtKB:Q08CC1 (1) | 573 aa |
No data available
- Huang, L., Zhang, L., Huo, H.J., Hou, J., Niu, M.M., Nie, P., Chen, S.N. (2023) FTR33, a member of fish-specific TRIM (finTRIM) subfamily, regulates negatively type I IFN antiviral immunity in zebrafish. Developmental and comparative immunology. 142:104671104671
- Li, R.F., Wang, Y.S., Lu, F.I., Huang, Y.S., Chiu, C.C., Tai, M.H., Wu, C.Y. (2022) Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 10(6)
- Lv, S., Zhang, Y., Zheng, J., Huang, X., Huang, Y., Qin, Q. (2019) Negative regulation of the interferon response by finTRIM82 in the orange spotted grouper. Fish & shellfish immunology. 88:391-402
- Langevin, C., Levraud, J.P., Boudinot, P. (2018) Fish antiviral tripartite motif (TRIM) proteins. Fish & shellfish immunology. 86:724-733
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Chang, H.W., Wang, W.D., Chiu, C.C., Chen, C.H., Wang, Y.S., Chen, Z.Y., Liu, W., Tai, M.H., Wen, Z.H., Wu, C.Y. (2017) Ftr82 Is Critical for Vascular Patterning during Zebrafish Development. International Journal of Molecular Sciences. 18(1)
- Langevin, C., Aleksejeva, E., Houel, A., Briolat, V., Torhy, C., Lunazzi, A., Levraud, J.P., Boudinot, P. (2017) FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Frontiers in immunology. 8:617
- Luo, K., Li, Y., Ai, K., Xia, L., Zhang, J., Hu, W., Gao, W., Guo, L., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Bioinformatics and expression analysis of finTRIM genes in grass carp, Ctenopharyngodon idella. Fish & shellfish immunology. 66:217-223
- Luo, K., Li, Y., Xia, L., Hu, W., Gao, W., Guo, L., Tian, G., Qi, Z., Yuan, H., Qiaoqing, X. (2017) Analysis of the expression patterns of the novel large multigene TRIM gene family (finTRIM) in zebrafish. Fish & shellfish immunology. 66:224-230
- Wu, Y., Lou, Q.Y., Ge, F., Xiong, Q. (2017) Quantitative Proteomics Analysis Reveals Novel Targets of miR-21 in Zebrafish Embryos. Scientific Reports. 7:4022
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