Gene
unc119b
- ID
- ZDB-GENE-030219-130
- Name
- unc-119 lipid binding chaperone B
- Symbol
- unc119b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Involved in cilium assembly. Acts upstream of or within Kupffer's vesicle development and nervous system development. Predicted to be located in cell projection. Predicted to be active in cilium. Is expressed in several structures, including mesoderm; nervous system; neural plate; pronephric duct; and spinal cord neural tube. Orthologous to human UNC119B (unc-119 lipid binding chaperone B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111863 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wright et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GMP phosphodiesterase, delta subunit | GMP phosphodiesterase, delta subunit superfamily | Immunoglobulin E-set | PDE6D/unc-119 myristoyl-binding |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q9J8 | InterPro | 261 | ||||
| UniProtKB:Q90Z08 | InterPro | 243 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
unc119.1-201
(1)
|
Ensembl | 5,284 nt | ||
| ncRNA |
unc119.1-002
(1)
|
Ensembl | 540 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-117K10 | ZFIN Curated Data | |
| Encodes | EST | fc47b02 | ZFIN Curated Data | |
| Encodes | EST | ibd2212 | ||
| Encodes | cDNA | MGC:111863 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193872 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193886 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212787 (1) | 1678 nt | ||
| Genomic | GenBank:CR376731 (1) | 130762 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q9J8 (1) | 261 aa |
- Jean, F., Pilgrim, D. (2019) Evolution and expression of the zebrafish unc119 paralogues indicates a conserved role in cilia. Gene expression patterns : GEP. 33:1-10
- Rainy, N., Etzion, T., Alon, S., Pomeranz, A., Nisgav, Y., Livnat, T., Bach, M., Gerstner, C.D., Baehr, W., Gothilf, Y., Stiebel-Kalish, H. (2016) Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish. Biochemical and Biophysical Research Communications. 473(4):1211-7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wright, K.J., Baye, L.M., Olivier-Mason, A., Mukhopadhyay, S., Sang, L., Kwong, M., Wang, W., Pretorius, P.R., Sheffield, V.C., Sengupta, P., Slusarski, D.C., and Jackson, P.K. (2011) An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes & Development. 25(22):2347-2360
- Manning, A.G., Crawford, B.D., Waskiewicz, A.J., and Pilgrim, D.B. (2004) UNC-119 homolog required for normal development of the zebrafish nervous system. Genesis (New York, N.Y. : 2000). 40(4):223-230
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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