Gene
quob
- ID
- ZDB-GENE-030131-9944
- Name
- quattro b
- Symbol
- quob Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within animal organ morphogenesis and mesoderm morphogenesis. Is expressed in several structures, including Kupffer's vesicle; anterior axial hypoblast; forerunner cell group; mesoderm; and nervous system. Orthologous to human KIAA1755 (KIAA1755).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb9 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7021 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10332 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa17343 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26650 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33788 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-quob | von der Heyde et al., 2020 | |
| MO1-quob | N/A | (2) |
| MO2-quob | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dbl homology (DH) domain superfamily | Dbl homology domain | PH-like domain superfamily | Pleckstrin homology domain | Rho GEF and signaling-related domain-containing protein | SOS1/NGEF-like, PH domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6DN89 | InterPro | 1989 | ||||||
| UniProtKB:A0A8M1N225 | InterPro | 1987 | ||||||
| UniProtKB:A0AB32TQS0 | InterPro | 1988 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-441C13 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-1393C1 | ZFIN Curated Data | |
| Encodes | EST | cb9 | Thisse et al., 2001 | |
| Encodes | EST | fb97g10 | ||
| Encodes | cDNA | MGC:193981 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004109 (1) | 6455 nt | ||
| Genomic | GenBank:FP236186 (2) | 36867 nt | ||
| Polypeptide | UniProtKB:Q6DN89 (1) | 1989 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human PLEKHG4 based on amino acid similarity. Subsequent analysis suggests it is the ortholog of human KIAA1755 and mouse D630003M21Rik based on amino acid similarity and conserved synteny.
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- von der Heyde, B., Emmanouilidou, A., Mazzaferro, E., Vicenzi, S., Höijer, I., Klingström, T., Jumaa, S., Dethlefsen, O., Snieder, H., de Geus, E., Ameur, A., Ingelsson, E., Allalou, A., Brooke, H.L., den Hoed, M. (2020) Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach. Scientific Reports. 10:11831
- Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wang, X., Zhao, Z., Muller, J., Iyu, A., Khng, A.J., Guccione, E., Ruan, Y., and Ingham, P.W. (2013) Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish. Biology Open. 2(11):1203-1213
- Tse, S.W., Broderick, J.A., Wei, M.L., Luo, M.H., Smith, D., McCaffery, P., Stamm, S., and Andreadis, A. (2005) Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain. Gene. 359:63-72
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Daggett, D.F., Boyd, C.A,. Gautier, P., Bryson-Richardson, R.J., Thisse, C., Thisse, B., Amacher, S.L., and Currie, P.D. (2004) Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Current biology : CB. 14(18):632-638
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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