Gene
rhpn2
- ID
- ZDB-GENE-030131-9927
- Name
- rhophilin, Rho GTPase binding protein 2
- Symbol
- rhpn2 Nomenclature History
- Previous Names
-
- cb668 (1)
- sb:cb668
- wu:fa26b12
- wu:fk87d04
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including EVL; axis; nervous system; periderm; and pronephric duct. Orthologous to several human genes including RHPN2 (rhophilin Rho GTPase binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb668 (30 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016106Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026041Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026042Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1319 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa10688 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21021 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004328 | BRO1 domain |
| Domain | IPR011072 | HR1 rho-binding domain |
| Domain | IPR047902 | Rhophilin-2, BRO1 domain |
| Domain | IPR049603 | Rhophilin-2, HR1 domain |
| Family | IPR047138 | Rhophilin-1/2 |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036274 | HR1 repeat superfamily |
| Homologous_superfamily | IPR038499 | BRO1 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | BRO1 domain | BRO1 domain superfamily | HR1 repeat superfamily | HR1 rho-binding domain | PDZ domain | PDZ superfamily | Rhophilin-1/2 | Rhophilin-2, BRO1 domain | Rhophilin-2, HR1 domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BG90 | InterPro | 673 | |||||||||
| UniProtKB:Q6TNR1 | InterPro | 683 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-134O20 | ZFIN Curated Data | |
| Encodes | EST | cb668 | Thisse et al., 2001 | |
| Encodes | EST | fa26b12 | ZFIN Curated Data | |
| Encodes | EST | fk87d04 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55960 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201178 (1) | 2233 nt | ||
| Genomic | GenBank:BX323855 (1) | 124192 nt | ||
| Polypeptide | UniProtKB:Q6TNR1 (1) | 683 aa |
- Ellingsen, S., Narawane, S., Fjose, A., Verri, T., Rønnestad, I. (2021) The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9). Fish physiology and biochemistry. 47(5):1507-1525
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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