Gene

cpox

ID
ZDB-GENE-030131-9884
Name
coproporphyrinogen oxidase
Symbol
cpox Nomenclature History
Previous Names
  • cpo (1)
  • cb535 (1)
  • im:7156501
  • sb:cb535
  • wu:fc43a01
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have coproporphyrinogen oxidase activity. Involved in hemoglobin biosynthetic process. Predicted to localize to mitochondrial intermembrane space. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Is expressed in hematopoietic system; mesoderm; presumptive blood; and ventral mesenchyme. Orthologous to human CPOX (coproporphyrinogen oxidase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cpox Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary coproporphyria Alliance Coproporphyria 121300
Harderoporphyria 618892
Associated With cpox Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018375 Coproporphyrinogen III oxidase, conserved site
Family IPR001260 Coproporphyrinogen III oxidase, aerobic
Homologous_superfamily IPR036406 Oxygen-dependent coproporphyrinogen III oxidase superfamily
Domain Details Per Protein
Protein Length Coproporphyrinogen III oxidase, aerobic Coproporphyrinogen III oxidase, conserved site Oxygen-dependent coproporphyrinogen III oxidase superfamily
UniProtKB:Q1LY08 449
UniProtKB:Q05AK3 449
UniProtKB:Q1XIH8 449
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations