Gene
rspo3
- ID
- ZDB-GENE-030131-9814
- Name
- R-spondin 3
- Symbol
- rspo3 Nomenclature History
- Previous Names
-
- cb387 (1)
- sb:cb387
- wu:fa13e08
- zgc:162040
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity. Acts upstream of or within several processes, including pectoral fin development; posterior lateral line neuromast development; and regulation of odontogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranium; digestive system; endoderm; forebrain neural keel; and nervous system. Orthologous to human RSPO3 (R-spondin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb387 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-rspo3 | Alhazmi et al., 2021 | |
MO1-rspo3 | N/A | Rong et al., 2014 |
MO2-rspo3 | N/A | Rong et al., 2014 |
MO3-rspo3 | N/A | Matsuda et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR043601 | R-spondin, Fu-CRD domain |
Domain | IPR044004 | Spondin-like TSP1 domain |
Family | IPR051514 | R-spondin domain-containing protein |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
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Domain Details Per Protein
Protein | Additional Resources | Length | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | R-spondin domain-containing protein | R-spondin, Fu-CRD domain | Spondin-like TSP1 domain | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B4I7 | InterPro | 248 | |||||||
UniProtKB:Q5R328 | InterPro | 317 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-195P4 | ZFIN Curated Data | |
Contained in | BAC | DKEY-242E21 | ZFIN Curated Data | |
Encodes | EST | cb387 | Thisse et al., 2001 | |
Encodes | EST | fa13e08 | ZFIN Curated Data | |
Encodes | cDNA | MGC:162040 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001017358 (1) | 2193 nt | ||
Genomic | GenBank:BX470182 (2) | 199742 nt | ||
Polypeptide | UniProtKB:Q5R328 (1) | 317 aa |
- Alhazmi, N., Carroll, S.H., Kawasaki, K., Woronowicz, K.C., Hallett, S.A., Macias Trevino, C., Li, E.B., Baron, R., Gori, F., Yelick, P.C., Harris, M.P., Liao, E.C. (2021) Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Scientific Reports. 11:5871
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Loh, N.Y., Minchin, J.E.N., Pinnick, K.E., Verma, M., Todorčević, M., Denton, N., Moustafa, J.E., Kemp, J.P., Gregson, C.L., Evans, D.M., Neville, M.J., Small, K.S., McCarthy, M.I., Mahajan, A., Rawls, J.F., Karpe, F., Christodoulides, C. (2020) RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. Nature communications. 11:2797
- Niu, J., Guan, J., Li, R., Li, X., Zhai, J., Qi, J., He, Y. (2018) Cynoglossus semilaevis Rspo3 Regulates Embryo Development by Inhibiting the Wnt/β-Catenin Signaling Pathway.. International Journal of Molecular Sciences. 19(7)
- Wang, B., Yang, F., Li, R., Li, X., Wu, X., Sun, Z., Zhai, J., He, Y., Qi, J. (2018) Functional characterization of Cynoglossus semilaevis R-spondin2 and its role in muscle development during embryogenesis. Genes & genetic systems. 93(5):181-190
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wincent, E., Stegeman, J.J., Jönsson, M.E. (2015) Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Toxicology and applied pharmacology. 284(2):163-79
- Rong, X., Chen, C., Zhou, P., Zhou, Y., Li, Y., Lu, L., Liu, Y., Zhou, J., Duan, C. (2014) R-Spondin 3 Regulates Dorsoventral and Anteroposterior Patterning by Antagonizing Wnt/β-Catenin Signaling in Zebrafish Embryos. PLoS One. 9(6):e99514
- Matsuda, M., Nogare, D.D., Somers, K., Martin, K., Wang, C., and Chitnis, A.B. (2013) Lef1 regulates Dusp6 to influence neuromast formation and spacing in the zebrafish posterior lateral line primordium. Development (Cambridge, England). 140(11):2387-2397
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