Gene

mbd3b

ID

ZDB-GENE-030131-9792

Name

methyl-CpG binding domain protein 3b

Symbol

mbd3b Nomenclature History

Previous Names

cb357 (1)
cb99 (1)
sb:cb357
sb:cb99
wu:fc41c05
zgc:111851

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have several functions, including ATP binding activity; actin filament binding activity; and motor activity. Involved in definitive hemopoiesis and hematopoietic progenitor cell differentiation. Predicted to localize to myosin complex and nucleus. Is expressed in several structures, including Kupffer's vesicle; central nervous system; forerunner cell group; midbrain neural keel; and retina. Orthologous to human MBD3 (methyl-CpG binding domain protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

cb99 (8 images)
cb357 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mbd3b Human Ortholog

No data available

Associated With mbd3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR001609	Myosin head, motor domain
Domain	IPR001739	Methyl-CpG DNA binding
Domain	IPR002710	Dilute domain
Domain	IPR025884	Methyl-CpG binding protein 2/3, C-terminal domain
Domain	IPR032343	Methyl-CpG-binding domain protein 2/3, p55-binding region
Domain	IPR036103	Class V myosin, motor domain
Family	IPR037965	Methyl-CpG-binding domain protein 3
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR016177	DNA-binding domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	Class V myosin, motor domain	Dilute domain	DNA-binding domain superfamily	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Methyl-CpG-binding domain protein 2/3, p55-binding region	Methyl-CpG-binding domain protein 3	Methyl-CpG binding protein 2/3, C-terminal domain	Methyl-CpG DNA binding	Myosin head, motor domain	Myosin S1 fragment, N-terminal	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q7ZZR0 InterPro	242
UniProtKB:F1QXS0 InterPro	1031
UniProtKB:A0A0R4IA78 InterPro	265
UniProtKB:F1QPJ2 InterPro	401
UniProtKB:A0A2R8QPC3 InterPro	265
UniProtKB:Q1LXS3 InterPro	184
UniProtKB:F1QL92 InterPro	242