ZFIN ID: ZDB-GENE-030131-9771
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: marker of proliferation Ki-67
Gene Symbol: mki67    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb31 (1), sb:cb31 (1), si:ch211-250b22.7 (1), wu:fa11g09, wu:fb57a07, wu:fi14e05

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Human ortholog(s) of this gene implicated in Crohn's disease; breast cancer; human immunodeficiency virus infectious disease; and pancreatic cancer. Is expressed in several structures, including blood; head; pectoral fin bud; pectoral fin musculature; and ventral mesoderm. Orthologous to human MKI67 (marker of proliferation Ki-67).
Genome Resources: Alliance (1),  Gene:564521 (1),  Ensembl(GRCz11):ENSDARG00000091150 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2001 [cb31]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12798 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa31859 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mki67 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mki67 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000253 Forkhead-associated (FHA) domain
    Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
    Repeat IPR012568 KI67R
    Domain IPR029334 Protein phosphatase 1 binding domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mki67-201 (1)    Ensembl 8187
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mki67 No data available
    MARKER RELATIONSHIPS
    mki67 Contained in: [BAC] CH73-389D14 (1), CH211-250B22 (1)
    mki67 Encodes: [EST] cb31 (1) (order this), fa11g09, fb57a07, fi14e05, wz11862
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001277446 (1)
    Select Tool
    Genomic GenBank:CR848037 (1) 101727 bp
    Select Tool
    Polypeptide UniProtKB:E7F3N4 (1) 2057 aa
    Select Tool
    Sequence Information (all 28)
    ORTHOLOGY for mki67 ( Chr: 12 )
    CITATIONS (18)