Gene

hmcn2

ID

ZDB-GENE-030131-9765

Name

hemicentin 2

Symbol

hmcn2 Nomenclature History

Previous Names

cb30 (1)
sb:cb30 (1)
si:ch211-204c5.1

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity. Involved in several processes, including embryonic medial fin morphogenesis; mesenchymal cell migration; and skin morphogenesis. Is expressed in several structures, including axis; median fin fold; mesoderm; myotome; and trunk. Orthologous to human HMCN2 (hemicentin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb30 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hmcn2 Human Ortholog

No data available

Associated With hmcn2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR006605	G2 nidogen/fibulin G2F
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Domain	IPR026823	Complement Clr-like EGF domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR050958	Cell Adhesion and Cytoskeletal Organization
Homologous_superfamily	IPR009017	Green fluorescent protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat

Domain Details Per Protein

Protein	Length	Cell Adhesion and Cytoskeletal Organization	Complement Clr-like EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	G2 nidogen/fibulin G2F	Green fluorescent protein	Growth factor receptor cysteine-rich domain superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Immunoglobulin V-set domain	NOTCH1 EGF-like calcium-binding domain	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily	von Willebrand factor A-like domain superfamily
UniProtKB:E7EY71 InterPro	1126
UniProtKB:E7F3V2 InterPro	4212

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hmcn2-202 (1) Ensembl	Ensembl	3,205 nt	Select Tool
mRNA	hmcn2-203 (1) Ensembl	Ensembl	266 nt	Select Tool
mRNA	hmcn2-204 (1) Ensembl	Ensembl	365 nt	Select Tool
mRNA	hmcn2-205 (1) Ensembl	Ensembl	472 nt	Select Tool
mRNA	hmcn2-206 (1) Ensembl	Ensembl	880 nt	Select Tool
mRNA	hmcn2-207 (1) Ensembl	Ensembl	2,585 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-hmcn2	polyclonal	hmcn2		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations