Gene
usp39
- ID
- ZDB-GENE-030131-966
- Name
- ubiquitin specific peptidase 39
- Symbol
- usp39 Nomenclature History
- Previous Names
-
- wu:fb54d10
- wu:fb79f05
- zgc:158428
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity and zinc ion binding activity. Acts upstream of or within adenohypophysis morphogenesis; cranial skeletal system development; and regulation of RNA splicing. Predicted to be part of spliceosomal complex. Is expressed in brain; eye; immature eye; and intermediate cell mass of mesoderm. Orthologous to human USP39 (ubiquitin specific peptidase 39).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ríos et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-usp39 | Prieto-Garcia et al., 2024 | |
| CRISPR2-usp39 | Prieto-Garcia et al., 2024 | |
| CRISPR3-usp39 | Prieto-Garcia et al., 2024 | |
| CRISPR4-usp39 | Prieto-Garcia et al., 2024 | |
| MO1-usp39 | N/A | (2) |
| MO2-usp39 | N/A | Ríos et al., 2011 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease domain | USP39 | Zinc finger, RING/FYVE/PHD-type | Zinc finger, UBP-type |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A1A5Z2 | InterPro | 497 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-283H6 | ZFIN Curated Data | |
| Encodes | EST | fb54d10 | ||
| Encodes | EST | fb79f05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158428 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080070 (1) | 1874 nt | ||
| Genomic | GenBank:BX537304 (1) | 157564 nt | ||
| Polypeptide | UniProtKB:A1A5Z2 (1) | 497 aa |
- Prieto-Garcia, C., Matkovic, V., Mosler, T., Li, C., Liang, J., Oo, J.A., Haidle, F., Mačinković, I., Cabrera-Orefice, A., Berkane, R., Giuliani, G., Xu, F., Jacomin, A.C., Tomaskovic, I., Basoglu, M., Hoffmann, M.E., Rathore, R., Cetin, R., Boutguetait, D., Bozkurt, S., Hernández Cañás, M.C., Keller, M., Busam, J., Shah, V.J., Wittig, I., Kaulich, M., Beli, P., Galej, W.P., Ebersberger, I., Wang, L., Münch, C., Stolz, A., Brandes, R.P., Tse, W.K.F., Eimer, S., Stainier, D.Y.R., Legewie, S., Zarnack, K., Müller-McNicoll, M., Dikic, I. (2024) Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy. Science (New York, N.Y.). 386:768776768-776
- Kuretani, A., Yamamoto, T., Taira, M., Michiue, T. (2021) Evolution of hes gene family in vertebrates: the hes5 cluster genes have specifically increased in frogs. BMC ecology and evolution. 21:147
- Tse, W.K.F. (2017) Importance of deubiquitinases in zebrafish craniofacial development. Biochemical and Biophysical Research Communications. 487(4):813-819
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ríos, Y., Melmed, S., Lin, S., and Liu, N.A. (2011) Zebrafish usp39 Mutation Leads to rb1 mRNA Splicing Defect and Pituitary Lineage Expansion. PLoS Genetics. 7(1):e1001271
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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