Gene

si:dkey-220f10.4

ID

ZDB-GENE-030131-9651

Name

si:dkey-220f10.4

Symbol

si:dkey-220f10.4 Nomenclature History

Previous Names

cb105 (1)
sb:cb105

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to be involved in protein localization to cilium. Predicted to be active in cilium. Is expressed in epiphysis; retina; and retinal photoreceptor layer. Orthologous to human TULP2 (TUB like protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2001

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb105 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa1568	Allele with one point mutation	Unknown	Premature Stop	ENU
sa14354	Allele with one point mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35277	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa35278	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With si:dkey-220f10.4 Human Ortholog

No data available

Associated With si:dkey-220f10.4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018066	Tubby, C-terminal, conserved site
Domain	IPR000007	Tubby, C-terminal
Homologous_superfamily	IPR025659	Tubby-like, C-terminal

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Domain Details Per Protein

Protein	Additional Resources	Length	Tubby, C-terminal	Tubby, C-terminal, conserved site	Tubby-like, C-terminal
UniProtKB:A0A8M2B775	InterPro	555
UniProtKB:Q1L8C0	InterPro	556

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 12

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:dkey-220f10.4-201 (1) Ensembl	Ensembl	1,771 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-220f10.4-202 (1) Ensembl	Ensembl	1,671 nt	Select Tool ZFIN BLAST
ncRNA	si:dkey-220f10.4-002 (1) Ensembl	Ensembl	684 nt	Select Tool ZFIN BLAST
ncRNA	si:dkey-220f10.4-003 (1) Ensembl	Ensembl	532 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-220F10	CR926135	ZFIN Curated Data
Encodes	EST	cb105	BI850043	Thisse et al., 2001

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_003199599 (1)	2035 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR383677 (1)	164387 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q1L8C0 (1)	556 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance

No data available

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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