Gene
aif1l
- ID
- ZDB-GENE-030131-9646
- Name
- allograft inflammatory factor 1-like
- Symbol
- aif1l Nomenclature History
- Previous Names
-
- aif1
- cb10 (1)
- fa04b11
- sb:cb10
- wu:fa04b11
- wu:fi14f08
- zgc:73179
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and calcium ion binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Predicted to be located in cytoskeleton. Predicted to colocalize with actin filament and ruffle membrane. Is expressed in several structures, including alar plate midbrain region; fin; immature eye; nervous system; and periderm. Orthologous to human AIF1L (allograft inflammatory factor 1 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb10 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Allograft inflammatory factor 1 | Allograft inflammatory factor 1-like, EF-hand domain pair | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|---|
| UniProtKB:Q6PBZ5 | InterPro | 148 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-198E16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-35I22 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-245L10 | ZFIN Curated Data | |
| Contains | SNP | rs3727888 | ZFIN Curated Data | |
| Contains | SNP | rs3727889 | ZFIN Curated Data | |
| Contains | STS | chunp30063 | ||
| Encodes | EST | cb10 | Thisse et al., 2001 | |
| Encodes | EST | fa04b11 | ||
| Encodes | EST | fi14f08 | ||
| Encodes | cDNA | MGC:73179 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198870 (1) | 2263 nt | ||
| Genomic | GenBank:BX571730 (1) | 160875 nt | ||
| Polypeptide | UniProtKB:Q6PBZ5 (1) | 148 aa |
- Ranasinghe, T., Seo, Y., Park, H.C., Choe, S.K., Cha, S.H. (2024) Rotenone exposure causes features of Parkinson`s disease pathology linked with muscle atrophy in developing zebrafish embryo. Journal of hazardous materials. 480:136215136215
- Mizoguchi, T., Okita, M., Minami, Y., Fukunaga, M., Maki, A., Itoh, M. (2023) Age-dependent dysfunction of the cerebrovascular system in the zebrafish telencephalon. Experimental gerontology. 178:112206
- Sahashi, D., Kubo, Y., Ishi, M., Ikeda, A., Yamasaki, C., Komatsu, M., Shiozaki, K. (2022) Neu1 deficiency increases the susceptibility of zebrafish to Edwardsiella piscicida infection via lysosomal dysfunction. Gene. 836:146667
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Veth, K.N., Willer, J.R., Collery, R.F., Gray, M.P., Willer, G.B., Wagner, D.S., Mullins, M.C., Udvadia, A.J., Smith, R.S., John, S.W., Gregg, R.G., and Link, B.A. (2011) Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma. PLoS Genetics. 7(2):e1001310
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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