Gene

pikfyve

ID
ZDB-GENE-030131-9636
Name
phosphoinositide kinase, FYVE finger containing
Symbol
pikfyve Nomenclature History
Previous Names
  • pip5k3
  • wu:fo93c03
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-phosphate 5-kinase activity; ATP binding activity; and metal ion binding activity. Predicted to be involved in intracellular signal transduction; phosphatidylinositol metabolic process; and phosphorylation. Localizes to membrane and perinuclear region of cytoplasm. Is expressed in several structures, including brain; digestive system; eye; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pikfyve Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fleck corneal dystrophy Alliance Corneal fleck dystrophy 121850
Associated With pikfyve Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000306 FYVE zinc finger
Domain IPR000591 DEP domain
Domain IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
Domain IPR017455 Zinc finger, FYVE-related
Domain IPR037378 PIKfyve, DEP domain
Family IPR002423 Chaperonin Cpn60/TCP-1 family
Family IPR043548 1-phosphatidylinositol-3phosphate-5-kinase
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR027409 GroEL-like apical domain superfamily
Homologous_superfamily IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length 1-phosphatidylinositol-3phosphate-5-kinase Chaperonin Cpn60/TCP-1 family DEP domain FYVE zinc finger GroEL-like apical domain superfamily Phosphatidylinositol-4-phosphate 5-kinase, core Phosphatidylinositol-4-phosphate 5-kinase, N-terminal PIKfyve, DEP domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily Zinc finger, FYVE/PHD-type Zinc finger, FYVE-related Zinc finger, RING/FYVE/PHD-type
UniProtKB:B2KTE1 2100
UniProtKB:B2KTE2 2084
UniProtKB:Q7SZQ5 941
UniProtKB:A0A2R8RNV7 2089
UniProtKB:B2KTE3 2091
UniProtKB:A0A2R8QAJ5 2105
UniProtKB:F8W3P1 140
UniProtKB:B2KTE4 2075
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations