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ZIRC
ZFIN ID: ZDB-GENE-030131-9636
Gene Name: phosphoinositide kinase, FYVE finger containing
Gene Symbol: pikfyve    Nomenclature History

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Previous Names: pip5k3, wu:fo93c03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have 1-phosphatidylinositol-3-phosphate 5-kinase activity; ATP binding activity; and metal ion binding activity. Predicted to be involved in intracellular signal transduction; phosphatidylinositol metabolic process; and phosphorylation. Localizes to the membrane and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Is expressed in several structures, including brain; digestive system; eye; muscle; and pleuroperitoneal region. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).
Genome Resources: Alliance (1),  Gene:337690 (1),  Ensembl(GRCz11):ENSDARG00000056112 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026909Tg Transgenic Insertion Unknown Unknown DNA
la026910Tg Transgenic Insertion Unknown Unknown DNA
sa12649 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15086 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21515 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41455 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pikfyve HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fleck corneal dystrophy Alliance Corneal fleck dystrophy 121850
    DISEASE ASSOCIATED WITH pikfyve VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intracellular signal transduction (more)
    Cellular Component membrane (more)
    Molecular Function 1-phosphatidylinositol-3-phosphate 5-kinase activity (more)
    GO Terms (all 12)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript pikfyve-205 (1)    Ensembl 866
    mRNA pikfyve-203 (1)    Ensembl 6303
    pikfyve-204 (1)    Ensembl 6933
    pikfyve-206 (1)    Ensembl 6238
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pikfyve No data available
    MARKER RELATIONSHIPS
    pikfyve Contained in: [BAC] DKEY-83M22 (1) (order this)
    pikfyve Encodes: [EST] eu745 (1), fo93c03, IMAGE:6792852
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001127305 (1) 6303 bp
    Genomic GenBank:BX530407 (1) 292409 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QAJ5 (1) 2105 aa
    Sequence Clusters UniGene:79456 (1)
    Sequence Information (all 49)
    ORTHOLOGY for pikfyve ( Chr: 9 )
    CITATIONS (24)