Gene
f13a1b
- ID
- ZDB-GENE-030131-9634
- Name
- coagulation factor XIII, A1 polypeptide b
- Symbol
- f13a1b Nomenclature History
- Previous Names
-
- f13a1
- fo83d04
- FX111a-87 (1)
- wu:fo83d04
- zgc:153334
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation and peptide cross-linking. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Is expressed in pectoral fin and retina. Orthologous to human F13A1 (coagulation factor XIII A chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| factor XIII deficiency | Alliance | Factor XIIIA deficiency | 613225 |
| prothrombin thrombophilia | Alliance | {Venous thrombosis, protection against} | 188050 |
| thrombophilia due to thrombin defect | Alliance | {Venous thrombosis, protection against} | 188050 |
| {Myocardial infarction, protection against} | 608446 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001102 | Transglutaminase, N-terminal |
| Domain | IPR002931 | Transglutaminase-like |
| Domain | IPR008958 | Transglutaminase, C-terminal |
| Family | IPR023608 | Protein-glutamine gamma-glutamyltransferase, animal |
| Family | IPR050779 | Protein-glutamine gamma-glutamyltransferases |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR036238 | Transglutaminase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036985 | Transglutaminase-like superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | Papain-like cysteine peptidase superfamily | Protein-glutamine gamma-glutamyltransferase, animal | Protein-glutamine gamma-glutamyltransferases | Transglutaminase, C-terminal | Transglutaminase, C-terminal domain superfamily | Transglutaminase-like | Transglutaminase-like superfamily | Transglutaminase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QC25
|
742 | ||||||||||
|
UniProtKB:Q08CA3
|
742 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
f13a1b-201
(1)
|
Ensembl | 5,899 nt | ||
| mRNA |
f13a1b-202
(1)
|
Ensembl | 3,162 nt | ||
| mRNA |
f13a1b-203
(1)
|
Ensembl | 2,233 nt | ||
| mRNA |
f13a1b-204
(1)
|
Ensembl | 2,568 nt |
Interactions and Pathways
No data available
Plasmids
No data available