ZFIN is now using GRCz12tu for Genomic Data
Gene
eif2b4
- ID
- ZDB-GENE-030131-955
- Name
- eukaryotic translation initiation factor 2B, subunit 4 delta
- Symbol
- eif2b4 Nomenclature History
- Previous Names
-
- si:ch211-101l18.4
- wu:fb54a09 (1)
- zgc:110790
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable translation initiation factor activity. Predicted to act upstream of or within translational initiation. Predicted to be located in cytosol. Is expressed in brain and eye. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 4. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110790 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 4 | Alliance | Leukoencephalopathy with vanishing white matter 4, with or without ovarian failure | 620314 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Initiation factor 2B-like, C-terminal | Initiation factor 2B-related | NagB/RpiA transferase-like |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2B7A3 | InterPro | 541 | |||
| UniProtKB:Q5RIE1 | InterPro | 540 | |||
| UniProtKB:A0A8M2B7A1 | InterPro | 555 | |||
| UniProtKB:A0A286Y8J6 | InterPro | 554 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2b4-201
(1)
|
Ensembl | 2,120 nt | ||
| mRNA |
eif2b4-203
(1)
|
Ensembl | 578 nt | ||
| mRNA |
eif2b4-205
(1)
|
Ensembl | 6,263 nt | ||
| ncRNA |
eif2b4-002
(1)
|
Ensembl | 794 nt | ||
| ncRNA |
eif2b4-004
(1)
|
Ensembl | 639 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers