Gene
plcg2
- ID
- ZDB-GENE-030131-9532
- Name
- phospholipase C, gamma 2
- Symbol
- plcg2 Nomenclature History
- Previous Names
-
- fj85b03
- sb:eu1064
- si:ch211-260p9.2
- wu:fj85b03
- zgc:152893
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have phosphatidylinositol phospholipase C activity. Predicted to be involved in several processes, including inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1064 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoinflammation, antibody deficiency, and immune dysregulation syndrome | Alliance | Autoinflammation, antibody deficiency, and immune dysregulation syndrome | 614878 |
| familial cold autoinflammatory syndrome 3 | Alliance | Familial cold autoinflammatory syndrome 3 | 614468 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000008 | C2 domain |
| Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR035023 | PLC-gamma, C-terminal SH2 domain |
| Domain | IPR035024 | PLC-gamma, N-terminal SH2 domain |
| Domain | IPR035723 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain |
| Family | IPR001192 | Phosphoinositide phospholipase C family |
| Family | IPR016279 | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain | C2 domain | C2 domain superfamily | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-gamma, C-terminal SH2 domain | PLC-gamma, N-terminal SH2 domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LWV8
|
1240 |
Interactions and Pathways
No data available
Plasmids
No data available