Gene

yrk

ID

ZDB-GENE-030131-9517

Name

Yes-related kinase

Symbol

yrk Nomenclature History

Previous Names

fj84d04
wu:fj84d04 (1)
zgc:92165

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within macrophage chemotaxis. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in blood island; cardiovascular system; head; mesoderm; and post-vent region. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159437 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yrk Human Ortholog

No data available

Associated With yrk Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000980	SH2 domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR001452	SH3 domain
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR035693	Tyrosine-protein kinase Fgr, SH2 domain
Family	IPR050198	Non-receptor tyrosine kinases involved in cell signaling
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	Non-receptor tyrosine kinases involved in cell signaling	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase Fgr, SH2 domain
UniProtKB:Q8AWF1 InterPro	525

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	yrk-201 (1) Ensembl	Ensembl	3,705 nt	Select Tool ZFIN BLAST
mRNA	yrk-203 (1) Ensembl	Ensembl	406 nt	Select Tool ZFIN BLAST
mRNA	yrk-204 (1) Ensembl	Ensembl	3,768 nt	Select Tool ZFIN BLAST
mRNA	yrk-205 (1) Ensembl	Ensembl	567 nt	Select Tool ZFIN BLAST
mRNA	yrk-206 (1) Ensembl	Ensembl	717 nt	Select Tool ZFIN BLAST
mRNA	yrk-207 (1) Ensembl	Ensembl	3,028 nt	Select Tool ZFIN BLAST
mRNA	yrk-208 (1) Ensembl	Ensembl	3,524 nt	Select Tool ZFIN BLAST
ncRNA	yrk-004 (1) Ensembl	Ensembl	539 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations