Gene
sik1
- ID
- ZDB-GENE-030131-9446
- Name
- salt-inducible kinase 1
- Symbol
- sik1 Nomenclature History
- Previous Names
-
- fj78h07
- si:ch211-235e18.3
- wu:fj78h07
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in cellular response to glucose starvation; intracellular signal transduction; and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 30. Orthologous to several human genes including SIK1B (salt inducible kinase 1B (putative)).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
developmental and epileptic encephalopathy 30 | Alliance | Developmental and epileptic encephalopathy 30 | 616341 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR015940 | Ubiquitin-associated domain |
Domain | IPR034672 | Salt-Inducible kinase, catalytic domain |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Salt-Inducible kinase, catalytic domain | Serine/threonine-protein kinase, active site | Ubiquitin-associated domain |
---|---|---|---|---|---|---|---|
UniProtKB:B0S6K0
|
811 | ||||||
UniProtKB:A0A0G2L7B5
|
800 | ||||||
UniProtKB:A0A8M2BEV1
|
420 |
Interactions and Pathways
No data available
Plasmids
No data available