Gene
pepd
- ID
- ZDB-GENE-030131-9444
- Name
- peptidase D
- Symbol
- pepd Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable manganese ion binding activity and metalloaminopeptidase activity. Acts upstream of or within endocrine pancreas development and pancreas regeneration. Is expressed in blood vessel; eye; neural crest; optic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1000 (9 images)
- eu591 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from O'Hare et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| prolidase deficiency | Alliance | Prolidase deficiency | 170100 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001131 | Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site |
| Domain | IPR000994 | Peptidase M24 |
| Domain | IPR007865 | Aminopeptidase P, N-terminal |
| Homologous_superfamily | IPR029149 | Creatinase/Aminopeptidase P/Spt16, N-terminal |
| Homologous_superfamily | IPR036005 | Creatinase/aminopeptidase-like |
Domain Details Per Protein
| Protein | Length | Aminopeptidase P, N-terminal | Creatinase/aminopeptidase-like | Creatinase/Aminopeptidase P/Spt16, N-terminal | Peptidase M24 | Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A0G2KZA4
|
498 | |||||
|
UniProtKB:Q7SXT5
|
496 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available