Gene
plcd1b
- ID
- ZDB-GENE-030131-9435
- Name
- phospholipase C, delta 1b
- Symbol
- plcd1b Nomenclature History
- Previous Names
-
- DrPLC-delta 1B
- fj78d10
- wu:fj78d10
- zgc:55868
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be active in cytoplasm. Is expressed in lens; neuromast; and solid lens vesicle. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 3. Orthologous to human PLCD1 (phospholipase C delta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2005
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu915 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nonsyndromic congenital nail disorder 3 | Alliance | Nail disorder, nonsyndromic congenital, 3, (leukonychia) | 151600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000909 | Phosphatidylinositol-specific phospholipase C, X domain |
| Domain | IPR001711 | Phospholipase C, phosphatidylinositol-specific, Y domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR015359 | Phosphoinositide-specific phospholipase C, EF-hand-like domain |
| Domain | IPR046975 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain |
| Family | IPR001192 | Phosphoinositide phospholipase C family |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR017946 | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, EF-hand domain | C2 domain | C2 domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain pair | PH-like domain superfamily | Phosphatidylinositol-specific phospholipase C, X domain | Phosphoinositide phospholipase C family | Phosphoinositide-specific phospholipase C, EF-hand-like domain | Phospholipase C, phosphatidylinositol-specific, Y domain | PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily | Pleckstrin homology domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAJ8 | InterPro | 772 | ||||||||||||
| UniProtKB:Q7ZU40 | InterPro | 749 | ||||||||||||
| UniProtKB:A0AB32U0Q9 | InterPro | 751 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plcd1b-201
(1)
|
Ensembl | 3,042 nt |
Interactions and Pathways
No data available
Plasmids
No data available