Gene
moxd1
- ID
- ZDB-GENE-030131-9320
- Name
- monooxygenase, DBH-like 1
- Symbol
- moxd1 Nomenclature History
- Previous Names
-
- fj65c11
- si:dkeyp-119b4.5
- wu:fj65c11
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in extracellular space and secretory granule membrane. Orthologous to human MOXD1 (monooxygenase DBH like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-moxd1 | Fredlund et al., 2024 | |
| CRISPR2-moxd1 | Fredlund et al., 2024 | |
| CRISPR3-moxd1 | Fredlund et al., 2024 | |
| CRISPR4-moxd1 | Fredlund et al., 2024 | |
| CRISPR5-moxd1 | Fredlund et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000323 | Copper type II, ascorbate-dependent monooxygenase, N-terminal |
| Domain | IPR005018 | DOMON domain |
| Domain | IPR024548 | Copper type II ascorbate-dependent monooxygenase, C-terminal |
| Domain | IPR045266 | Copper-dependent monooxygenases, DOMON domain |
| Family | IPR000945 | Dopamine beta-hydroxylase-like |
| Family | IPR028460 | Tyramine beta-hydroxylase/Dopamine beta-hydroxylase |
| Homologous_superfamily | IPR008977 | PHM/PNGase F domain superfamily |
| Homologous_superfamily | IPR014784 | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal |
| Homologous_superfamily | IPR036939 | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Copper-dependent monooxygenases, DOMON domain | Copper type II ascorbate-dependent monooxygenase, C-terminal | Copper type II, ascorbate-dependent monooxygenase-like, C-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal | Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily | DOMON domain | Dopamine beta-hydroxylase-like | PHM/PNGase F domain superfamily | Tyramine beta-hydroxylase/Dopamine beta-hydroxylase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5TZ24 | InterPro | 614 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-266K12 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-119B4 | ZFIN Curated Data | |
| Encodes | EST | fj65c11 | ||
| Encodes | cDNA | MGC:162794 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045206 (1) | 1830 nt | ||
| Genomic | GenBank:BX323010 (1) | 176396 nt | ||
| Polypeptide | UniProtKB:Q5TZ24 (1) | 614 aa |
- Fredlund, E., Andersson, S., Hilgert, E., Monferrer, E., Álvarez-Hernán, G., Karakaya, S., Loontiens, S., Bek, J.W., Gregor, T., Lecomte, E., Magnusson, E., Miltenyte, E., Cabirol, M., Kyknas, M., Engström, N., Henriksson, M.A., Hammarlund, E., Rosenblum, J.S., Noguera, R., Speleman, F., van Nes, J., Mohlin, S. (2024) MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma. Science advances. 10:eado1583
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Huang, P., Xiong, S., Kang, J., Mei, J., Gui, J.F. (2018) Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver.. Frontiers in Physiology. 9:676
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shan, Y., Zhang, Y., Zhuo, X., Li, X., Peng, J., Fang, W. (2016) Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhacing macrophage migration. Fish & shellfish immunology. 54:179-87
- Benard, E.L., Roobol, S.J., Spaink, H.P., Meijer, A.H. (2014) Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and comparative immunology. 47(2):223-33
- Rodius, S., Nazarov, P.V., Nepomuceno-Chamorro, I.A., Jeanty, C., González-Rosa, J.M., Ibberson, M., da Costa, R.M., Xenarios, I., Mercader, N., Azuaje, F. (2014) Transcriptional response to cardiac injury in the zebrafish: systematic identification of genes with highly concordant activity across in vivo models. BMC Genomics. 15:852
- Dowling, J.J., Arbogast, S., Hur, J., Nelson, D.D., McEvoy, A., Waugh, T., Marty, I., Lunardi, J., Brooks, S.V., Kuwada, J.Y., and Ferreiro, A. (2012) Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Brain : a journal of neurology. 135(4):1115-1127
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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