Gene
npl
- ID
- ZDB-GENE-030131-926
- Name
- N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
- Symbol
- npl Nomenclature History
- Previous Names
-
- wu:fb53b06
- zgc:76930
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable N-acetylneuraminate lyase activity. Acts upstream of or within N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including fin bud; gut; muscle; vein; and yolk syncytial layer. Used to study myopathy. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6894589 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Wen et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-npl | N/A | Wen et al., 2018 |
| MO2-npl | N/A | Wen et al., 2018 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myopathy | WT + MO1-npl | control | Wen et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase-type TIM barrel | DapA-like | Schiff base-forming aldolase, conserved site |
|---|---|---|---|---|---|
| UniProtKB:A9C3P6 | InterPro | 307 | |||
| UniProtKB:Q6NYR8 | InterPro | 307 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-183C17 | ZFIN Curated Data | |
| Contained in | BAC | CH211-223C15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-150D12 | ZFIN Curated Data | |
| Encodes | EST | fb53b06 | ||
| Encodes | EST | IMAGE:6894589 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:76930 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174793 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207051 (1) | 1697 nt | ||
| Genomic | GenBank:CR382344 (1) | 182390 nt | ||
| Polypeptide | UniProtKB:A9C3P6 (1) | 307 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | NPL | 1 | Amino acid sequence comparison (1) |
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Wen, X.Y., Tarailo-Graovac, M., Brand-Arzamendi, K., Willems, A., Rakic, B., Huijben, K., Da Silva, A., Pan, X., El-Rass, S., Ng, R., Selby, K., Philip, A.M., Yun, J., Ye, X.C., Ross, C.J., Lehman, A.M., Zijlstra, F., Bakar, A.A., Drögemöller, B., Moreland, J., Wasserman, W.W., Vallance, H., van Scherpenzeel, M., Karbassi, F., Hoskings, M., Engelke, U., de Brouwer, A., Wevers, R.A., Pshezhetsky, A.V., van Karnebeek, C.D., Lefeber, D.J. (2018) Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function. JCI insight. 3(24):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cannon, J.E., Place, E.S., Eve, A.M., Bradshaw, C.R., Sesay, A., Morrell, N.W., and Smith, J.C. (2013) Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Mechanisms of Development. 130(2-3):122-131
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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