Gene

gars1

ID

ZDB-GENE-030131-9174

Name

glycyl-tRNA synthetase 1

Symbol

gars1 Nomenclature History

Previous Names

gars
mrn (1)
metronome (1)
si:dkey-276i5.1 (1)
wu:fb02f03 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to enable glycine-tRNA ligase activity. Acts upstream of or within swimming behavior; synaptic assembly at neuromuscular junction; and translation. Predicted to be active in mitochondrion. Is expressed in several structures, including anterior neural keel; central nervous system; digestive system; heart; and segmental plate. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7144596 (11 images)
IMAGE:7162501 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gars1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant distal hereditary motor neuronopathy 5	Alliance	Neuronopathy, distal hereditary motor, autosomal dominant 5	600794
Charcot-Marie-Tooth disease type 2D	Alliance	Charcot-Marie-Tooth disease, type 2D	601472
		Spinal muscular atrophy, infantile, James type	619042

Associated With gars1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Charcot-Marie-Tooth disease type 2	gars1^s266/s266	standard conditions	Malissovas et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000738	WHEP-TRS domain
Domain	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain	IPR004154	Anticodon-binding
Domain	IPR006195	Aminoacyl-tRNA synthetase, class II
Domain	IPR033731	Glycyl-tRNA synthetase-like core domain
Family	IPR002315	Glycyl-tRNA synthetase
Family	IPR027031	Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Homologous_superfamily	IPR009068	uS15/NS1, RNA-binding domain superfamily
Homologous_superfamily	IPR036621	Anticodon-binding domain superfamily
Homologous_superfamily	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)

Domain Details Per Protein

Protein	Additional Resources	Length	Aminoacyl-tRNA synthetase, class II	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)	Anticodon-binding	Anticodon-binding domain superfamily	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)	Glycyl-tRNA synthetase	Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2	Glycyl-tRNA synthetase-like core domain	uS15/NS1, RNA-binding domain superfamily	WHEP-TRS domain
UniProtKB:A0AB13A8A7	InterPro	749

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gars-201 (1) Ensembl	Ensembl		2,622 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-gars	polyclonal	gars1	IgG	Rabbit	WB	Abcam plc	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations