setd3

ID

ZDB-GENE-030131-9137

Name

SET domain containing 3, actin histidine methyltransferase

Symbol

setd3 Nomenclature History

Previous Names

fb01d12
wu:fb01d12
zgc:63842

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables histone H3K36 methyltransferase activity and transcription coactivator activity. Involved in positive regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Is expressed in telencephalon. Orthologous to human SETD3 (SET domain containing 3, actin N3(tau)-histidine methyltransferase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Diotel et al., 2015

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With setd3 Human Ortholog

No data available

Associated With setd3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001214	SET domain
Domain	IPR015353	Rubisco LSMT, substrate-binding domain
Domain	IPR044428	SETD3, SET domain
Family	IPR025785	Actin-histidine N-methyltransferase SETD3
Family	IPR050600	SETD3/SETD6 methyltransferase
Homologous_superfamily	IPR036464	Rubisco LSMT, substrate-binding domain superfamily
Homologous_superfamily	IPR046341	SET domain superfamily