Gene

cpn1

ID
ZDB-GENE-030131-9116
Name
carboxypeptidase N, polypeptide 1
Symbol
cpn1 Nomenclature History
Previous Names
  • cb1037 (1)
  • fa99g08
  • wu:fa99g08 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have metallocarboxypeptidase activity. Involved in cellular response to estrogen stimulus; liver development; and sprouting angiogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin cartilage; and vasculature. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Wu et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cpn1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
carboxypeptidase N deficiency Alliance Carboxypeptidase N deficiency 212070
Associated With cpn1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000834 Peptidase M14, carboxypeptidase A
Domain IPR033814 Carboxypeptidase N, N-terminal domain
Family IPR027063 Carboxypeptidase N catalytic chain
Homologous_superfamily IPR008969 Carboxypeptidase-like, regulatory domain superfamily
Domain Details Per Protein
Protein Length Carboxypeptidase-like, regulatory domain superfamily Carboxypeptidase N catalytic chain Carboxypeptidase N, N-terminal domain Peptidase M14, carboxypeptidase A
UniProtKB:A8WGN2 450
UniProtKB:U3JB00 582
UniProtKB:Q6NY94 450
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations