ZFIN is now using GRCz12tu for Genomic Data
Gene
cpn1
- ID
- ZDB-GENE-030131-9116
- Name
- carboxypeptidase N, polypeptide 1
- Symbol
- cpn1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metallocarboxypeptidase activity. Acts upstream of or within cellular response to estrogen stimulus and liver development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin cartilage; and vasculature. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1).
- Genome Resources
- Note
-
cpn1 is represented by three Ensembl gene models in GRCz11
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1037 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Wu et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| carboxypeptidase N deficiency | Alliance | Carboxypeptidase N deficiency | 212070 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR057246 | Zinc carboxypeptidases, zinc-binding region 1 |
| Binding_site | IPR057247 | Zinc carboxypeptidases, zinc-binding region 2 |
| Domain | IPR000834 | Peptidase M14, carboxypeptidase A |
| Family | IPR050753 | Peptidase M14 domain-containing protein |
| Homologous_superfamily | IPR008969 | Carboxypeptidase-like, regulatory domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Carboxypeptidase-like, regulatory domain superfamily | Peptidase M14, carboxypeptidase A | Peptidase M14 domain-containing protein | Zinc carboxypeptidases, zinc-binding region 1 | Zinc carboxypeptidases, zinc-binding region 2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NY94 | InterPro | 450 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers