Gene
mbd3a
- ID
- ZDB-GENE-030131-9077
- Name
- methyl-CpG binding domain protein 3a
- Symbol
- mbd3a Nomenclature History
- Previous Names
-
- wu:fa98f07
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable methyl-CpG binding activity. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in blastomere and pharyngeal arch 3-7 skeleton. Orthologous to human MBD3 (methyl-CpG binding domain protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Fillatre et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DNA-binding domain superfamily | Methyl-CpG-binding domain protein 2/3, p55-binding region | Methyl-CpG binding protein 2/3, C-terminal domain | Methyl-CpG DNA binding |
|---|---|---|---|---|---|---|
| UniProtKB:Q7ZTV2 | InterPro | 241 | ||||
| UniProtKB:Q6TGX7 | InterPro | 273 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-325M22 | ZFIN Curated Data | |
| Encodes | EST | fa98f07 | ||
| Encodes | EST | fb66a04 | Rauch et al., 2003 | |
| Encodes | EST | IMAGE:6908208 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7139207 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:86913 | ZFIN Curated Data |
1 - 6 of 6
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212769 (1) | 1857 nt | ||
| Genomic | GenBank:CU855938 (2) | 30644 nt | ||
| Polypeptide | UniProtKB:Q6TGX7 (1) | 273 aa |
- Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
- Gombeau, K., Bourdineaud, J.P., Ravanat, J.L., Armant, O., Camilleri, V., Cavalie, I., Floriani, M., Adam-Guillermin, C. (2017) Epigenetic, histopathological and transcriptomic effects following exposure to depleted uranium in adult zebrafish and their progeny. Aquatic toxicology (Amsterdam, Netherlands). 184:14-25
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Laing, L.V., Viana, J., Dempster, E.L., Trznadel, M., Trunkfield, L.A., Webster, T.M., van Aerle, R., Paull, G.C., Wilson, R.J., Mill, J., Santos, E.M. (2016) Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics. 11(7):526-38
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Pfefferli, C., Müller, F., Ja Wi Ska, A., Wicky, C. (2014) Specific NuRD components are required for fin regeneration in zebrafish. BMC Biology. 12:30
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Hendrich, B. and Tweedie, S. (2003) The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends in genetics : TIG. 19(5):269-277
1 - 10 of 11
Show