Gene
ndc80
- ID
- ZDB-GENE-030131-904
- Name
- NDC80 kinetochore complex component
- Symbol
- ndc80 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable kinetochore adaptor activity and microtubule binding activity. Predicted to be involved in mitotic sister chromatid biorientation; mitotic spindle organization; and positive regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Predicted to be part of Ndc80 complex. Is expressed in proliferative region. Orthologous to human NDC80 (NDC80 kinetochore complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:111801 (10 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2080Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi2857Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| sa1896 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14319 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16762 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa22044 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38875 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41971 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Domain of unknown function DUF5595 | Kinetochore protein Ndc80 | Kinetochore protein Ndc80, CH domain | Ndc80 domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DRJ7 | InterPro | 632 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-250B22 | ZFIN Curated Data | |
| Contains | STS | chunp30189 | ||
| Contains | STS | chunp30327 | ||
| Encodes | EST | fb52e02 | ||
| Encodes | cDNA | MGC:111801 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003863 (1) | 2280 nt | ||
| Genomic | GenBank:CR848037 (1) | 101727 nt | ||
| Polypeptide | UniProtKB:Q6DRJ7 (1) | 632 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
- McCurley, A.T., and Callard, G.V. (2010) Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration. Journal of experimental neuroscience. 2010(4):17-33
- Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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