Gene
acadvl
- ID
- ZDB-GENE-030131-899
- Name
- acyl-CoA dehydrogenase very long chain
- Symbol
- acadvl Nomenclature History
- Previous Names
-
- vlcad (1)
- fb52d04
- wu:fb52d04
- wu:fc75e01
- zgc:64067
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have fatty-acyl-CoA binding activity and very-long-chain-acyl-CoA dehydrogenase activity. Involved in head development. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Is expressed in female organism; pectoral fin musculature; and pronephric duct. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64067 (6 images)
- IMAGE:7162137 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Carvalho et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| very long chain acyl-CoA dehydrogenase deficiency | Alliance | VLCAD deficiency | 201475 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR006089 | Acyl-CoA dehydrogenase, conserved site |
| Domain | IPR006091 | Acyl-CoA oxidase/dehydrogenase, middle domain |
| Domain | IPR009075 | Acyl-CoA dehydrogenase/oxidase, C-terminal |
| Domain | IPR013786 | Acyl-CoA dehydrogenase/oxidase, N-terminal |
| Domain | IPR049448 | ACAD9/ACADV-like, C-terminal domain |
| Homologous_superfamily | IPR009100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily |
| Homologous_superfamily | IPR036250 | Acyl-CoA dehydrogenase-like, C-terminal |
| Homologous_superfamily | IPR037069 | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily |
| Homologous_superfamily | IPR046373 | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily |
Domain Details Per Protein
| Protein | Length | ACAD9/ACADV-like, C-terminal domain | Acyl-CoA dehydrogenase, conserved site | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase, C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase/dehydrogenase, middle domain | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2C2
|
659 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acadvl-201
(1)
|
Ensembl | 2,572 nt | ||
| mRNA |
acadvl-202
(1)
|
Ensembl | 3,536 nt |
Interactions and Pathways
No data available
Plasmids
No data available