Gene
dnajc21
- ID
- ZDB-GENE-030131-8928
- Name
- DnaJ heat shock protein family (Hsp40) member C21
- Symbol
- dnajc21 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be active in cytoplasm. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Mueller et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bone marrow failure syndrome 3 | 617052 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chaperone J-domain superfamily | DnaJ domain | DnaJ domain, conserved site | Matrin/U1-C-like, C2H2-type zinc finger | Multifunctional chaperone and stress response protein | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger, double-stranded RNA binding | Zuotin-like, zuotin homology domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6PGY5
|
545 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnajc21-201
(1)
|
Ensembl | 2,247 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Ketharnathan, S., Pokharel, S., Prykhozhij, S.V., Cordeiro-Santanach, A., Ban, K., Dogan, S., Hoang, H.D., Liebman, M.F., Leung, E., Alain, T., Alecu, I., Bennett, S.A.L., Čuperlović-Culf, M., Dror, Y., Berman, J.N. (2024) Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish. Leukemia. 38(10):2115-2126
- Mueller, R.L., Huang, C., and Ho, R.K. (2010) Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation. BMC Genomics. 11:492
- Jima, D.D., Shah, R.N., Orcutt, T.M., Joshi, D., Law, J.M., Litman, G.W., Trede, N.S., and Yoder, J.A. (2009) Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity. Molecular immunology. 46(7):1505-1516
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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