Gene
ttc8
- ID
- ZDB-GENE-030131-8846
- Name
- tetratricopeptide repeat domain 8
- Symbol
- ttc8 Nomenclature History
- Previous Names
-
- bbs8 (1)
- fk26c02
- wu:fk26c02
- zgc:136718
- Type
- protein_coding_gene
- Location
- Unmapped
- Description
- Acts upstream of or within several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of pigment granule localization. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8).
- Genome Resources
-
- Alliance (1)
- Gene:678551 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Tobin et al., 2008
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Bardet-Biedl syndrome 8 | Alliance | Bardet-Biedl syndrome 8 | 615985 |
| retinitis pigmentosa 51 | Alliance | ?Retinitis pigmentosa 51 | 613464 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| ciliopathy | WT + MO3-ttc8 | control | Tobin et al., 2008 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Tetratricopeptide repeat protein 8 |
|---|---|---|---|---|---|
| UniProtKB:Q1RLX7 | InterPro | 507 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance