Gene

ttc8

ID
ZDB-GENE-030131-8846
Name
tetratricopeptide repeat domain 8
Symbol
ttc8 Nomenclature History
Previous Names
  • bbs8 (1)
  • fk26c02
  • wu:fk26c02
  • zgc:136718
Type
protein_coding_gene
Location
Unmapped
Description
Acts upstream of or within several processes, including Kupffer's vesicle development; embryonic morphogenesis; and establishment of pigment granule localization. Predicted to be part of BBSome. Predicted to be active in ciliary basal body and non-motile cilium. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 8; and retinitis pigmentosa 51. Orthologous to human TTC8 (tetratricopeptide repeat domain 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Tobin et al., 2008
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ttc8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bardet-Biedl syndrome 8 Alliance Bardet-Biedl syndrome 8 615985
retinitis pigmentosa 51 Alliance ?Retinitis pigmentosa 51 613464
1 - 2 of 2
Associated With ttc8 Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO3-ttc8 control Tobin et al., 2008
1 - 1 of 1
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR028796 Tetratricopeptide repeat protein 8
Homologous_superfamily IPR011990 Tetratricopeptide-like helical domain superfamily
Repeat IPR019734 Tetratricopeptide repeat
1 - 3 of 3
Domain Details Per Protein
Protein Additional Resources Length Tetratricopeptide-like helical domain superfamily Tetratricopeptide repeat Tetratricopeptide repeat protein 8
UniProtKB:Q1RLX7 InterPro 507
1 - 1 of 1
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations