Gene
rps15a
- ID
- ZDB-GENE-030131-8708
- Name
- ribosomal protein S15a
- Symbol
- rps15a Nomenclature History
- Previous Names
-
- wu:fb04b07
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of ribosome. Acts upstream of or within several processes, including brain development; chordate embryonic development; and erythrocyte differentiation. Predicted to be located in cytoplasm; nucleolus; and ribosome. Predicted to be part of cytosolic small ribosomal subunit and small-subunit processome. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 20. Orthologous to human RPS15A (ribosomal protein S15a).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi2649Tg | Transgenic insertion | Intron 1 | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rps15a | N/A | Uechi et al., 2006 |
| MO2-rps15a | N/A | Ikeda et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diamond-Blackfan anemia 20 | Alliance | ?Diamond-Blackfan anemia 20 | 618313 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Small ribosomal subunit protein uS8 | Small ribosomal subunit protein uS8, conserved site | Small ribosomal subunit protein uS8 superfamily |
|---|---|---|---|---|---|
| UniProtKB:Q6Q420 | InterPro PDB | 130 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rps15a-202
(1)
|
Ensembl | 721 nt | ||
| mRNA |
rps15a-203
(1)
|
Ensembl | 438 nt | ||
| ncRNA |
rps15a-002
(1)
|
Ensembl | 811 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-156B7 | ZFIN Curated Data | |
| Encodes | EST | fb04b07 | ||
| Encodes | cDNA | MGC:123121 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212762 (1) | 442 nt | ||
| Genomic | GenBank:CR450821 (1) | 163751 nt | ||
| Polypeptide | UniProtKB:Q6Q420 (1) | 130 aa |
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Ikeda, F., Yoshida, K., Toki, T., Uechi, T., Ishida, S., Nakajima, Y., Sasahara, Y., Okuno, Y., Kanezaki, R., Terui, K., Kamio, T., Kobayashi, A., Fujita, T., Sato-Otsubo, A., Shiraishi, Y., Tanaka, H., Chiba, K., Muramatsu, H., Kanno, H., Ohga, S., Ohara, A., Kojima, S., Kenmochi, N., Miyano, S., Ogawa, S., Ito, E. (2017) Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia.. Haematologica. 102:e93-e96
- Lee, J., Freeman, J.L. (2016) Embryonic exposure to 10 μg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer's disease in aged adult zebrafish brain. Metallomics : integrated biometal science. 8(6):589-96
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Wu, C.C., Tsai, T.H., Chang, C., Lee, T.T., Lin, C., Cheng, I.H., Sun, M.C., Chuang, Y.J., Chen, B.S. (2014) On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio. PLoS One. 9:e97902
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Cambier, S., Gonzalez, P., Durrieu, G., Maury-Brachet, R., Boudou, A., and Bourdineaud, J.P. (2010) Serial analysis of gene expression in the skeletal muscles of zebrafish fed with a methylmercury-contaminated diet. Environmental science & technology. 44(1):469-475
- Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences of the United States of America. 107(39):16940-16945
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