Gene
cyfip1
- ID
- ZDB-GENE-030131-8557
- Name
- cytoplasmic FMR1 interacting protein 1
- Symbol
- cyfip1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable RNA 7-methylguanosine cap binding activity; actin filament binding activity; and translation repressor activity. Acts upstream of or within with a positive effect on axon extension. Predicted to be located in cytoplasm. Predicted to be part of SCAR complex. Predicted to be active in neuron projection and synapse. Is expressed in dorsal telencephalon. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144298 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Cioni et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2288 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10367 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14676 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20750 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40737 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45259 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| uab381 | Allele with one delins | Unknown | Unknown | CRISPR |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cyfip1 | Cioni et al., 2018 | |
| CRISPR2-cyfip1 | Edwards et al., 2020 |
1 - 2 of 2
Show
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CYRIA/CYRIB, Rac1 binding domain | Cytoplasmic FMR1-interacting |
|---|---|---|---|
|
UniProtKB:Q90YM8
|
1253 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyfip1-201
(1)
|
Ensembl | 4,645 nt | ||
| mRNA |
cyfip1-202
(1)
|
Ensembl | 1,654 nt | ||
| ncRNA |
cyfip1-003
(1)
|
Ensembl | 510 nt | ||
| ncRNA |
cyfip1-004
(1)
|
Ensembl | 515 nt |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-125I12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-62E6 | ZFIN Curated Data | |
| Encodes | EST | fb15a06 | ||
| Encodes | EST | IMAGE:7144298 | Thisse et al., 2004 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212759 (1) | 4127 nt | ||
| Genomic | GenBank:BX322552 (1) | 230846 nt | ||
| Polypeptide | UniProtKB:Q90YM8 (1) | 1253 aa |
- Yergert, K.M., Doll, C.A., O'Rouke, R., Hines, J.H., Appel, B. (2021) Identification of 3' UTR motifs required for mRNA localization to myelin sheaths in vivo. PLoS Biology. 19:e3001053
- Edwards, J.J., Rouillard, A.D., Fernandez, N.F., Wang, Z., Lachmann, A., Shankaran, S.S., Bisgrove, B.W., Demarest, B., Turan, N., Srivastava, D., Bernstein, D., Deanfield, J., Giardini, A., Porter, G., Kim, R., Roberts, A.E., Newburger, J.W., Goldmuntz, E., Brueckner, M., Lifton, R.P., Seidman, C.E., Chung, W.K., Tristani-Firouzi, M., Yost, H.J., Ma'ayan, A., Gelb, B.D. (2020) Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC. Basic to translational science. 5:376-386
- Messina, A., Boiti, A., Vallortigara, G. (2020) Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience. 53(2):362-375
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Cioni, J.M., Wong, H.H., Bressan, D., Kodama, L., Harris, W.A., Holt, C.E. (2018) Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function. Neuron. 97:1078-1093.e6
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Baraban, S.C., Dinday, M.T., and Hortopan, G.A. (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nature communications. 4:2410
- Rapkins, R.W., Hore, T., Smithwick, M., Ager, E., Pask, A.J., Renfree, M.B., Kohn, M., Hameister, H., Nicholls, R.D., Deakin, J.E., and Graves, J.A. (2006) Recent assembly of an imprinted domain from non-imprinted components. PLoS Genetics. 2(10):e182
- Schenck, A., Bardoni, B., Moro, A., Bagni, C., and Mandel, J.L. (2001) A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proceedings of the National Academy of Sciences of the United States of America. 98(15):8844-8849
1 - 10 of 10
Show