Gene
ppiaa
- ID
- ZDB-GENE-030131-8556
- Name
- peptidylprolyl isomerase Aa (cyclophilin A)
- Symbol
- ppiaa Nomenclature History
- Previous Names
-
- ppia
- fa93g09
- wu:fa93g09
- wu:fb05e11
- wu:fb13h02
- wu:fb15a05
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within apoptotic process and protein peptidyl-prolyl isomerization. Predicted to be located in extracellular region and nucleus. Predicted to be active in cytoplasm. Is expressed in adipose tissue; cerebellum; digestive system; eye; and midbrain. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to several human genes including PPIA (peptidylprolyl isomerase A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6901511 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020892 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
| Domain | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Family | IPR024936 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase |
| Homologous_superfamily | IPR029000 | Cyclophilin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclophilin-like domain superfamily | Cyclophilin-type peptidyl-prolyl cis-trans isomerase | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q6TNR5 | InterPro | 164 |
Interactions and Pathways
No data available
Plasmids
No data available