Gene
nup62l
- ID
- ZDB-GENE-030131-8491
- Name
- nucleoporin 62 like
- Symbol
- nup62l Nomenclature History
- Previous Names
-
- fb13d02
- wu:fb13d02 (1)
- zgc:172056
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable phospholipid binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within several processes, including canonical Wnt signaling pathway involved in negative regulation of apoptotic process; digestive system development; and regulation of signal transduction. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including brain; head; intestine; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in primary biliary cholangitis and striatonigral degeneration. Orthologous to human NUP62 (nucleoporin 62).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yang et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nup62l | Yang et al., 2019 | |
| CRISPR2-nup62l | (2) | |
| MO1-nup62l | N/A | |
| MO2-nup62l | N/A | Yang et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Nucleoporin, NSP1-like, C-terminal | Nucleoporin NSP1/NUP62 |
|---|---|---|---|---|
| UniProtKB:A8WFZ2 | InterPro | 507 | ||
| UniProtKB:E9QIQ3 | InterPro | 507 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nup62l-201
(1)
|
Ensembl | 1,893 nt | ||
| mRNA |
nup62l-202
(1)
|
Ensembl | 775 nt | ||
| mRNA |
nup62l-203
(1)
|
Ensembl | 878 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-92I17 | ZFIN Curated Data | |
| Encodes | EST | fb13d02 | ||
| Encodes | cDNA | MGC:172056 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113596 (1) | 1670 nt | ||
| Genomic | GenBank:BX005453 (1) | 185541 nt | ||
| Polypeptide | UniProtKB:A8WFZ2 (1) | 507 aa |
No data available
- Shen, W., Gong, B., Xing, C., Zhang, L., Sun, J., Chen, Y., Yang, C., Yan, L., Chen, L., Yao, L., Li, G., Deng, H., Wu, X., Meng, A. (2022) Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell. 185(26):4954-4970.e20
- Wu, S., Chen, K., Xu, T., Ma, K., Gao, L., Fu, C., Zhang, W., Jing, C., Ren, C., Deng, M., Chen, Y., Zhou, Y., Pan, W., Jia, X. (2021) Tpr Deficiency Disrupts Erythroid Maturation With Impaired Chromatin Condensation in Zebrafish Embryogenesis. Frontiers in cell and developmental biology. 9:709923
- Yang, X., Li, X., Gu, Q., Li, Q., Cui, Z. (2019) Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 8(9):
- Yang, X., Gu, Q., Lin, L., Li, S., Zhong, S., Li, Q., Cui, Z. (2015) Nucleoporin 62-like protein activates canonical Wnt signaling through facilitating the nuclear import of β-catenin in zebrafish. Molecular and cellular biology. 35(7):1110-24
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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