Gene
tfg
- ID
- ZDB-GENE-030131-8410
- Name
- trafficking from ER to golgi regulator
- Symbol
- tfg Nomenclature History
- Previous Names
-
- wu:fb11c10
- zgc:55342
- zgc:77230
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have identical protein binding activity. Predicted to be involved in COPII vesicle coating. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55342 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa31722 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-tfg | N/A | Chen et al., 2022 |
MO2-tfg | N/A | Chen et al., 2022 |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Charcot-Marie-Tooth disease type 2 | Alliance | Hereditary motor and sensory neuropathy, Okinawa type | 604484 |
hereditary spastic paraplegia 57 | Alliance | ?Spastic paraplegia 57, autosomal recessive | 615658 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | PB1 domain | PB1-like domain | Protein TFG | TFG, PB1 domain |
---|---|---|---|---|---|
UniProtKB:Q6P0G5
|
396 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-283E2 | ZFIN Curated Data | |
Encodes | EST | fb11c10 | ||
Encodes | cDNA | MGC:55342 | ZFIN Curated Data | |
Encodes | cDNA | MGC:77230 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_200015 (1) | 1892 nt | ||
Genomic | GenBank:BX322575 (1) | 149874 nt | ||
Polypeptide | UniProtKB:Q6P0G5 (1) | 396 aa |
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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