Gene
trps1
- ID
- ZDB-GENE-030131-8404
- Name
- trichorhinophalangeal syndrome I
- Symbol
- trps1 Nomenclature History
- Previous Names
-
- wu:fb11b10
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in osteochondrodysplasia; trichorhinophalangeal syndrome type I; and trichorhinophalangeal syndrome type III. Orthologous to human TRPS1 (transcriptional repressor GATA binding 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| j1271aGt | Transgenic insertion | Intron 1 | Unknown | DNA | |
| la010239Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la020883Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028071Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9617 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9881 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29269 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| trichorhinophalangeal syndrome type I | Alliance | Trichorhinophalangeal syndrome, type I | 190350 |
| trichorhinophalangeal syndrome type III | Alliance | Trichorhinophalangeal syndrome, type III | 190351 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Transcription factor TRPS1 | Zinc finger C2H2-type | Zinc finger, GATA-type | Zinc finger, NHR/GATA-type |
|---|---|---|---|---|---|---|
| UniProtKB:D4P0Z5 | InterPro | 1243 | ||||
| UniProtKB:A0A8M3AL78 | InterPro | 1243 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-168A14 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-3G2 | ZFIN Curated Data | |
| Contains | SNP | rs3729001 | ZFIN Curated Data | |
| Encodes | EST | fb11b10 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001177934 (1) | 4617 nt | ||
| Genomic | GenBank:CT737154 (2) | 167298 nt | ||
| Polypeptide | UniProtKB:A0A8M3AL78 (1) | 1243 aa |
- Abrar, M., Ali, S., Hussain, I., Khatoon, H., Batool, F., Ghazanfar, S., Corcoran, D., Kawakami, Y., Abbasi, A.A. (2024) Cis-regulatory control of mammalian Trps1 gene expression. Journal of experimental zoology. Part B, Molecular and developmental evolution. 342(2):85-100
- Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K. (2022) Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1306-1321
- Smeeton, J., Natarajan, N., Anderson, T., Tseng, K.C., Fabian, P., Crump, J.G. (2022) Regeneration of Jaw Joint Cartilage in Adult Zebrafish. Frontiers in cell and developmental biology. 9:777787
- Farmer, D.T., Patel, P., Choi, R., Liu, C.Y., Crump, J.G. (2021) Comprehensive series of Irx cluster mutants reveals diverse roles in facial cartilage development. Development (Cambridge, England). 148(16)
- Smeeton, J., Natarajan, N., Naveen Kumar, A., Miyashita, T., Baddam, P., Fabian, P., Graf, D., Crump, J.G. (2021) Zebrafish Model for Spondylo-Megaepiphyseal-Metaphyseal Dysplasia Reveals Post-Embryonic Roles of Nkx3.2 in the Skeleton. Development (Cambridge, England). 148(2):
- Barske, L., Fabian, P., Hirschberger, C., Jandzik, D., Square, T., Xu, P., Nelson, N., Yu, H.V., Medeiros, D.M., Gillis, J.A., Crump, J.G. (2020) Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24876-24884
- Giffen, K.P., Liu, H., Kramer, K.L., He, D.Z. (2019) Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Frontiers in neuroscience. 13:1117
- Askary, A., Smeeton, J., Paul, S., Schindler, S., Braasch, I., Ellis, N.A., Postlethwait, J., Miller, C.T., Crump, J.G. (2016) Ancient origin of lubricated joints in bony vertebrates. eLIFE. 5
- Askary, A., Mork, L., Paul, S., He, X., Izuhara, A.K., Gopalakrishnan, S., Ichida, J.K., McMahon, A.P., Dabizljevic, S., Dale, R., Mariani, F.V., Crump, J.G. (2015) Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Developmental Cell. 35:358-65
- Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Developmental Biology. 385(2):189-99
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