Gene

gnai2a

ID

ZDB-GENE-030131-8365

Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a

Symbol

gnai2a Nomenclature History

Previous Names

gnai2l
Galpha i2b (1)
wu:fb10b04
wu:fb19c04
zgc:92609

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to localize to heterotrimeric G-protein complex. Is expressed in several structures, including head; nervous system; paraxial mesoderm; pronephric duct; and vein. Orthologous to human GNAI2 (G protein subunit alpha i2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92609 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnai2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pituitary adenoma, ACTH-secreting, somatic
		Ventricular tachycardia, idiopathic	192605

Associated With gnai2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
Family	IPR001408	G-protein alpha subunit, group I
Homologous_superfamily	IPR011025	G protein alpha subunit, helical insertion
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase