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ZIRC
ZFIN ID: ZDB-GENE-030131-8325
Gene Name: coactosin-like F-actin binding protein 1
Gene Symbol: cotl1    Nomenclature History

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Previous Names: wu:fb08h08, zgc:63983

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to colocalize with the actin filament. Is expressed in blood; epidermis; and periderm. Orthologous to human COTL1 (coactosin like F-actin binding protein 1).
Genome Resources: Alliance (1),  Gene:336381 (1),  Ensembl(GRCz11):ENSDARG00000026829 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 4 figures (5 images) from Thisse et al., 2004 [MGC:63983]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa39194 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43066 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45633 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cotl1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cotl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of actin filament polymerization (more)
    Cellular Component COLOCALIZES_WITH   actin filament (more)
    Molecular Function actin binding (more)
    GO Terms (all 7)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cotl1-201 (1)    Ensembl 1398
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cotl1 No data available
    MARKER RELATIONSHIPS
    cotl1 Contained in: [BAC] CH73-77K24 (1) (order this), CH211-260P9 (1) (order this)
    cotl1 Encodes: [EST] fb08h08
    [cDNA] MGC:63983 (1) (order this), MGC:158169 (1) (order this), MGC:191411 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200012 (1) 1348 bp
    Genomic GenBank:BX511124 (1) 149227 bp
    Select Tool
    Polypeptide UniProtKB:Q6PFT7 (1) 142 aa
    Sequence Clusters UniGene:1242 (1)
    Sequence Information (all 22)
    ORTHOLOGY for cotl1 ( Chr: 18 )
    CITATIONS (22)