Gene
ptprja
- ID
- ZDB-GENE-030131-8301
- Name
- protein tyrosine phosphatase receptor type Ja
- Symbol
- ptprja Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within artery morphogenesis and thrombocyte differentiation. Predicted to be located in cell projection and plasma membrane. Is expressed in blood vessel endothelial cell; brain; and muscle. Used to study thrombocytopenia. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung squamous cell carcinoma; and thrombocytopenia. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, somatic | 114500 |
| Thrombocytopenia 10 | 620484 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | la2Tg + CRISPR2-ptprja | standard conditions | Marconi et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR041201 | PTPRJ, transmembrane domain |
| Family | IPR050713 | Receptor-type Tyrosine-protein Phosphatases/Ushers |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTPRJ, transmembrane domain | Receptor-type Tyrosine-protein Phosphatases/Ushers | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BE01
|
1766 | ||||||||||
|
UniProtKB:A0A8M9Q1N4
|
1683 | ||||||||||
|
UniProtKB:B6HY54
|
1650 | ||||||||||
|
UniProtKB:A0A8M2BDT9
|
1766 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptprja-203
(1)
|
Ensembl | 5,618 nt | ||
| ncRNA |
ptprja-002
(1)
|
Ensembl | 493 nt | ||
| ncRNA |
ptprja-003
(1)
|
Ensembl | 423 nt |
Interactions and Pathways
No data available
Plasmids
No data available