Gene
ptprja
- ID
- ZDB-GENE-030131-8301
- Name
- protein tyrosine phosphatase receptor type Ja
- Symbol
- ptprja Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within artery morphogenesis and thrombocyte differentiation. Predicted to be located in membrane. Is expressed in blood vessel endothelial cell; brain; and muscle. Used to study thrombocytopenia. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; and lung squamous cell carcinoma. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| colorectal cancer | Alliance | Colon cancer, somatic | 114500 |
| Thrombocytopenia 10 | 620484 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | la2Tg + CRISPR2-ptprja | standard conditions | Marconi et al., 2018 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000242 | Tyrosine-specific protein phosphatase, PTPase domain |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR041201 | PTPRJ, transmembrane domain |
| Family | IPR050713 | Receptor-type Tyrosine-protein Phosphatases/Ushers |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | PTPRJ, transmembrane domain | Receptor-type Tyrosine-protein Phosphatases/Ushers | Tyrosine-specific protein phosphatase, PTPase domain | Tyrosine-specific protein phosphatases domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BE01
|
1766 | ||||||||||
|
UniProtKB:A0A8M9Q1N4
|
1683 | ||||||||||
|
UniProtKB:B6HY54
|
1650 | ||||||||||
|
UniProtKB:A0A8M2BDT9
|
1766 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptprja-203
(1)
|
Ensembl | 5,618 nt | ||
| ncRNA |
ptprja-002
(1)
|
Ensembl | 493 nt | ||
| ncRNA |
ptprja-003
(1)
|
Ensembl | 423 nt |
Interactions and Pathways
No data available
Plasmids
No data available