Gene
ak5
- ID
- ZDB-GENE-030131-8256
- Name
- adenylate kinase 5
- Symbol
- ak5 Nomenclature History
- Previous Names
-
- wu:fj63a06
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable nucleoside diphosphate kinase activity. Acts upstream of or within cilium assembly. Predicted to be active in cytosol.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shim et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023850Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023851Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023852Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2067 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18317 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa25759 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32843 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32844 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ak5 | N/A | Shim et al., 2016 |
| MO2-ak5 | N/A | Shim et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenylate kinase, conserved site | Adenylate kinase/UMP-CMP kinase | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
| UniProtKB:A5PMF1 | InterPro | 563 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199A5 | ZFIN Curated Data | |
| Contained in | BAC | CH211-226B21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-4D9 | ZFIN Curated Data | |
| Encodes | EST | fj63a06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001100084 (1) | 1692 nt | ||
| Genomic | GenBank:BX469891 (2) | 175261 nt | ||
| Polypeptide | UniProtKB:A5PMF1 (1) | 563 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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