Gene

cramp1

ID

ZDB-GENE-030131-8255

Name

cramped chromatin regulator homolog 1

Symbol

cramp1 Nomenclature History

Previous Names

cramp1l
fj63a04
si:dkey-91d10.8
wu:fj63a04 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable chromatin binding activity. Predicted to be involved in pattern specification process. Predicted to be active in nucleus. Orthologous to human CRAMP1 (cramped chromatin regulator homolog 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa12928	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa19969	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa40024	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With cramp1 Human Ortholog

No data available

Associated With cramp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR017884	SANT domain
Family	IPR055315	Cramped-like

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Domain Details Per Protein

Protein	Additional Resources	Length	Cramped-like	SANT domain
UniProtKB:A0A8M1RIJ0	InterPro	1132
UniProtKB:A0A8M2BAY9	InterPro	1115

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 3

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	cramp1-201 (1) Ensembl	Ensembl		6,374 nt	Select Tool ZFIN BLAST
mRNA	cramp1-202 (1) Ensembl	Ensembl		3,424 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-91D10	BX914211	ZFIN Curated Data
Encodes	EST	fj63a04	AW305719 AW419477

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_003198078 (1)	4797 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX914211 (1)	179226 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M1RIJ0 (1)	1132 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	CRAMP1	16	Ensembl:ENSG00000007545 Gene:57585 HGNC:14122	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Cramp1	17	Ensembl:ENSMUSG00000038002 Gene:57354 MGI:1930190	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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