Gene

ttbk2b

ID

ZDB-GENE-030131-8246

Name

tau tubulin kinase 2b

Symbol

ttbk2b Nomenclature History

Previous Names

fj62e10
sb:eu1102
si:dkey-12h9.11
si:dkey-12h9.14
wu:fj62e10

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cilium assembly and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu1102 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ttbk2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spinocerebellar ataxia type 11	Alliance	Spinocerebellar ataxia 11	604432

Associated With ttbk2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR047916	Tau-tubulin kinase homolog Asator-like, catalytic domain
Family	IPR050235	Casein Kinase 1 Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily