Gene

madd

ID

ZDB-GENE-030131-8076

Name

MAP-kinase activating death domain

Symbol

madd Nomenclature History

Previous Names

fj51a06
wu:fj51a06

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human MADD (MAP kinase activating death domain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With madd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		DEEAH syndrome	619004
		Neurodevelopmental disorder with dysmorphic facies, impaired speech and hypotonia	619005

Associated With madd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001194	cDENN domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR037516	Tripartite DENN domain
Family	IPR039980	MAP kinase-activating death domain protein
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe

Domain Details Per Protein

Protein	Length	cDENN domain	dDENN domain	DENN domain, C-terminal lobe	MAP kinase-activating death domain protein	Tripartite DENN domain	uDENN domain
UniProtKB:A0A8M9Q2H3 InterPro	1696
UniProtKB:A0A8M9PKV5 InterPro	1674
UniProtKB:A0A8M9PKV0 InterPro	1693
UniProtKB:A0A8M9PZ59 InterPro	1695
UniProtKB:A0A8M9Q8Q4 InterPro	1692
UniProtKB:A0A8M9Q2K0 InterPro	1622
UniProtKB:A0A8M9PPX3 InterPro	1626
UniProtKB:A0A8M3B1A8 InterPro	1599
UniProtKB:A0A8M9PRY0 InterPro	1692
UniProtKB:A0A8M9Q8R7 InterPro	1601
UniProtKB:A0A8M9QHU5 InterPro	1709
UniProtKB:A0A8M3AUB1 InterPro	1669
UniProtKB:A0A8M3B471 InterPro	1600
UniProtKB:A0A8M9QCV2 InterPro	1684
UniProtKB:A0A8M9P9N3 InterPro	1694
UniProtKB:A0A8M9PZ63 InterPro	1684
UniProtKB:A0A8M9PPW2 InterPro	1694
UniProtKB:A0A8M9PRY5 InterPro	1672
UniProtKB:A0A8M9PZ78 InterPro	1669
UniProtKB:A0A8M9PRZ4 InterPro	1622
UniProtKB:A0A8M9QHV7 InterPro	1644
UniProtKB:A0A8M9Q2G9 InterPro	1709
UniProtKB:A0A8M9PZ74 InterPro	1604
UniProtKB:A0A8M9QHW4 InterPro	1600
UniProtKB:A0A8M9QCW0 InterPro	1622
UniProtKB:A0A8M9PZ67 InterPro	1647
UniProtKB:A0A8M9PPY3 InterPro	1491
UniProtKB:A0A8M9PS03 InterPro	1580
UniProtKB:A0A8M9PRX6 InterPro	1697
UniProtKB:A0A8M9Q2K7 InterPro	1624
UniProtKB:A0A8M9PZ70 InterPro	1624
UniProtKB:A0A8M9Q2J9 InterPro	1693
UniProtKB:A0A8M9QCU0 InterPro	1717
UniProtKB:A0A8M3BB33 InterPro	1622
UniProtKB:A0A8M9PRZ8 InterPro	1600
UniProtKB:A0A8M9P9P0 InterPro	1645
UniProtKB:A0A8M9QCW5 InterPro	1554
UniProtKB:A0A8M9QHV2 InterPro	1690
UniProtKB:A0A8M9PKW4 InterPro	1622
UniProtKB:A0A8M9P9P4 InterPro	1623
UniProtKB:A0A8M9P9P8 InterPro	1601
UniProtKB:A0A8M3BB31 InterPro	1652
UniProtKB:A0A8M9Q2I3 InterPro	1652
UniProtKB:A0A8M9Q2J1 InterPro	1621
UniProtKB:A0A8M9QHW0 InterPro	1622
UniProtKB:A0A8M9P9Q1 InterPro	1600
UniProtKB:A0A8M9P9M5 InterPro	1716
UniProtKB:A0A8M9Q8P7 InterPro	1714
UniProtKB:A0A8M9PKU2 InterPro	1714
UniProtKB:A0A8M3AUB9 InterPro	1672
UniProtKB:A0A8M3AUB5 InterPro	1532
UniProtKB:A0A8M9Q8R3 InterPro	1623
UniProtKB:A0A8M9QCU8 InterPro	1695
UniProtKB:A0A8M9Q2I9 InterPro	1714
UniProtKB:A0A8M9Q2I7 InterPro	1626
UniProtKB:A0A8M9Q2H8 InterPro	1690
UniProtKB:A0A8M9PRY9 InterPro	1643
UniProtKB:A0A8M9Q2L1 InterPro	1604
UniProtKB:A0A8M9PPV3 InterPro	1716
UniProtKB:A0A8M3AUC3 InterPro	1580
UniProtKB:A0A8M9QCU3 InterPro	1707
UniProtKB:A0A8M9QCV6 InterPro	1643
UniProtKB:A0A8M9P9M9 InterPro	1704
UniProtKB:A0A8M9PPW8 InterPro	1674
UniProtKB:A0A8M9QHU8 InterPro	1696
UniProtKB:A0A8M9PRX1 InterPro	1714
UniProtKB:A0A8M9Q8Q0 InterPro	1697
UniProtKB:A0A8M9PZ55 InterPro	1707
UniProtKB:A0A8M9PPV7 InterPro	1704
UniProtKB:A0A8M9PKW0 InterPro	1644
UniProtKB:A0A8M9Q2J4 InterPro	1698
UniProtKB:A0A8M9PKX3 InterPro	1599
UniProtKB:A0A8M9Q2G4 InterPro	1717
UniProtKB:A0A8M9PZ84 InterPro	1532
UniProtKB:A0A8M9PPX8 InterPro	1621
UniProtKB:A0A8M9PKU6 InterPro	1698
UniProtKB:A0A8M9Q8Q9 InterPro	1647
UniProtKB:A0A8M9Q2J5 InterPro	1554

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	madd-201 (1) Ensembl	Ensembl	5,205 nt	Select Tool ZFIN BLAST
mRNA	madd-202 (1) Ensembl	Ensembl	450 nt	Select Tool ZFIN BLAST
mRNA	madd-205 (1) Ensembl	Ensembl	6,979 nt	Select Tool ZFIN BLAST
mRNA	madd-206 (1) Ensembl	Ensembl	182 nt	Select Tool ZFIN BLAST
mRNA	madd-208 (1) Ensembl	Ensembl	4,981 nt	Select Tool ZFIN BLAST
ncRNA	madd-004 (1) Ensembl	Ensembl	538 nt	Select Tool ZFIN BLAST
ncRNA	madd-005 (1) Ensembl	Ensembl	480 nt	Select Tool ZFIN BLAST
ncRNA	madd-006 (1) Ensembl	Ensembl	539 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations