Gene

madd

ID

ZDB-GENE-030131-8076

Name

MAP-kinase activating death domain

Symbol

madd Nomenclature History

Previous Names

fj51a06
wu:fj51a06

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human MADD (MAP kinase activating death domain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With madd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		DEEAH syndrome	619004
		Neurodevelopmental disorder with dysmorphic facies, impaired speech and hypotonia	619005

Associated With madd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001194	cDENN domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR037516	Tripartite DENN domain
Family	IPR039980	MAP kinase-activating death domain protein
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9Q2H3	InterPro	1696
UniProtKB:A0A8M9PKV5	InterPro	1674
UniProtKB:A0A8M9PKV0	InterPro	1693
UniProtKB:A0A8M9PZ59	InterPro	1695
UniProtKB:A0A8M9Q8Q4	InterPro	1692
UniProtKB:A0A8M9Q2K0	InterPro	1622
UniProtKB:A0A8M9PPX3	InterPro	1626
UniProtKB:A0A8M3B1A8	InterPro	1599
UniProtKB:A0A8M9PRY0	InterPro	1692
UniProtKB:A0A8M9Q8R7	InterPro	1601
UniProtKB:A0A8M9QHU5	InterPro	1709
UniProtKB:A0A8M3AUB1	InterPro	1669
UniProtKB:A0A8M3B471	InterPro	1600
UniProtKB:A0A8M9QCV2	InterPro	1684
UniProtKB:A0A8M9P9N3	InterPro	1694
UniProtKB:A0A8M9PZ63	InterPro	1684
UniProtKB:A0A8M9PPW2	InterPro	1694
UniProtKB:A0A8M9PRY5	InterPro	1672
UniProtKB:A0A8M9PZ78	InterPro	1669
UniProtKB:A0A8M9PRZ4	InterPro	1622
UniProtKB:A0A8M9QHV7	InterPro	1644
UniProtKB:A0A8M9Q2G9	InterPro	1709
UniProtKB:A0A8M9PZ74	InterPro	1604
UniProtKB:A0A8M9QHW4	InterPro	1600
UniProtKB:A0A8M9QCW0	InterPro	1622
UniProtKB:A0A8M9PZ67	InterPro	1647
UniProtKB:A0A8M9PPY3	InterPro	1491
UniProtKB:A0A8M9PS03	InterPro	1580
UniProtKB:A0A8M9PRX6	InterPro	1697
UniProtKB:A0A8M9Q2K7	InterPro	1624
UniProtKB:A0A8M9PZ70	InterPro	1624
UniProtKB:A0A8M9Q2J9	InterPro	1693
UniProtKB:A0A8M9QCU0	InterPro	1717
UniProtKB:A0A8M3BB33	InterPro	1622
UniProtKB:A0A8M9PRZ8	InterPro	1600
UniProtKB:A0A8M9P9P0	InterPro	1645
UniProtKB:A0A8M9QCW5	InterPro	1554
UniProtKB:A0A8M9QHV2	InterPro	1690
UniProtKB:A0A8M9PKW4	InterPro	1622
UniProtKB:A0A8M9P9P4	InterPro	1623
UniProtKB:A0A8M9P9P8	InterPro	1601
UniProtKB:A0A8M3BB31	InterPro	1652
UniProtKB:A0A8M9Q2I3	InterPro	1652
UniProtKB:A0A8M9Q2J1	InterPro	1621
UniProtKB:A0A8M9QHW0	InterPro	1622
UniProtKB:A0A8M9P9Q1	InterPro	1600
UniProtKB:A0A8M9P9M5	InterPro	1716
UniProtKB:A0A8M9Q8P7	InterPro	1714
UniProtKB:A0A8M9PKU2	InterPro	1714
UniProtKB:A0A8M3AUB9	InterPro	1672
UniProtKB:A0A8M3AUB5	InterPro	1532
UniProtKB:A0A8M9Q8R3	InterPro	1623
UniProtKB:A0A8M9QCU8	InterPro	1695
UniProtKB:A0A8M9Q2I9	InterPro	1714
UniProtKB:A0A8M9Q2I7	InterPro	1626
UniProtKB:A0A8M9Q2H8	InterPro	1690
UniProtKB:A0A8M9PRY9	InterPro	1643
UniProtKB:A0A8M9Q2L1	InterPro	1604
UniProtKB:A0A8M9PPV3	InterPro	1716
UniProtKB:A0A8M3AUC3	InterPro	1580
UniProtKB:A0A8M9QCU3	InterPro	1707
UniProtKB:A0A8M9QCV6	InterPro	1643
UniProtKB:A0A8M9P9M9	InterPro	1704
UniProtKB:A0A8M9PPW8	InterPro	1674
UniProtKB:A0A8M9QHU8	InterPro	1696
UniProtKB:A0A8M9PRX1	InterPro	1714
UniProtKB:A0A8M9Q8Q0	InterPro	1697
UniProtKB:A0A8M9PZ55	InterPro	1707
UniProtKB:A0A8M9PPV7	InterPro	1704
UniProtKB:A0A8M9PKW0	InterPro	1644
UniProtKB:A0A8M9Q2J4	InterPro	1698
UniProtKB:A0A8M9PKX3	InterPro	1599
UniProtKB:A0A8M9Q2G4	InterPro	1717
UniProtKB:A0A8M9PZ84	InterPro	1532
UniProtKB:A0A8M9PPX8	InterPro	1621
UniProtKB:A0A8M9PKU6	InterPro	1698
UniProtKB:A0A8M9Q8Q9	InterPro	1647
UniProtKB:A0A8M9Q2J5	InterPro	1554
UniProtKB:A0AB32TF74	InterPro	1710
UniProtKB:A0AB32TF78	InterPro	1703
UniProtKB:A0AB32TF87	InterPro	1642
UniProtKB:A0AB32TF96	InterPro	1642
UniProtKB:A0AB32TFA3	InterPro	1573
UniProtKB:A0AB32TFB3	InterPro	1572
UniProtKB:A0AB32TGN2	InterPro	1691
UniProtKB:A0AB32TGP4	InterPro	1640
UniProtKB:A0AB32TGQ5	InterPro	1579
UniProtKB:A0AB32TGR2	InterPro	1692
UniProtKB:A0AB32TGS8	InterPro	1641
UniProtKB:A0AB32TGU2	InterPro	1551
UniProtKB:A0AB32THV3	InterPro	1690
UniProtKB:A0AB32THW8	InterPro	1620
UniProtKB:A0AB32THY3	InterPro	1553
UniProtKB:A0AB32TIA6	InterPro	1701
UniProtKB:A0AB32TIB8	InterPro	1641
UniProtKB:A0AB32TIC8	InterPro	1572
UniProtKB:A0AB32TIG5	InterPro	1686
UniProtKB:A0AB32TII2	InterPro	1619
UniProtKB:A0AB32TIJ5	InterPro	1552
UniProtKB:A0AB32TIY3	InterPro	1684
UniProtKB:A0AB32TIZ9	InterPro	1616
UniProtKB:A0AB32TKF8	InterPro	1678
UniProtKB:A0AB32TKH1	InterPro	1615
UniProtKB:A0AB32TKU6	InterPro	1698
UniProtKB:A0AB32TKW2	InterPro	1641
UniProtKB:A0AB32TKY1	InterPro	1571
UniProtKB:A0AB32TLY7	InterPro	1661
UniProtKB:A0AB32TM03	InterPro	1592
UniProtKB:A0AB32TM33	InterPro	1711
UniProtKB:A0AB32TM47	InterPro	1649
UniProtKB:A0AB32TM64	InterPro	1591
UniProtKB:A0AB32TMA7	InterPro	1668
UniProtKB:A0AB32TMC2	InterPro	1595
UniProtKB:A0AB32TMN2	InterPro	1688
UniProtKB:A0AB32TMQ8	InterPro	1648
UniProtKB:A0AB32TNU6	InterPro	1663
UniProtKB:A0AB32TNW5	InterPro	1594
UniProtKB:A0AB32TSI4	InterPro	1692
UniProtKB:A0AB32TSJ8	InterPro	1691
UniProtKB:A0AB32TSK0	InterPro	1641
UniProtKB:A0AB32TSL2	InterPro	1640
UniProtKB:A0AB32TSL7	InterPro	1571
UniProtKB:A0AB32TSM5	InterPro	1551
UniProtKB:A0AB32TTE5	InterPro	1684
UniProtKB:A0AB32TTF8	InterPro	1616
UniProtKB:A0AB32TTH2	InterPro	1485
UniProtKB:A0AB32TTT8	InterPro	1686
UniProtKB:A0AB32TTV3	InterPro	1619
UniProtKB:A0AB32TTW9	InterPro	1508
UniProtKB:A0AB32TUZ8	InterPro	1663
UniProtKB:A0AB32TV11	InterPro	1600
UniProtKB:A0AB32TV26	InterPro	1648
UniProtKB:A0AB32TV33	InterPro	1678
UniProtKB:A0AB32TV49	InterPro	1615
UniProtKB:A0AB32TV63	InterPro	1579
UniProtKB:A0AB32TVX7	InterPro	1690
UniProtKB:A0AB32TVZ1	InterPro	1621
UniProtKB:A0AB32TW02	InterPro	1661
UniProtKB:A0AB32TW05	InterPro	1533
UniProtKB:A0AB32TW13	InterPro	1595
UniProtKB:A0AB32TW28	InterPro	1552
UniProtKB:A0AB32TXP3	InterPro	1688
UniProtKB:A0AB32TXQ3	InterPro	1649
UniProtKB:A0AB32TXQ7	InterPro	1620
UniProtKB:A0AB32TXR8	InterPro	1532
UniProtKB:A0AB32TXR9	InterPro	1592
UniProtKB:A0AB32TY97	InterPro	1703
UniProtKB:A0AB32TYB1	InterPro	1641
UniProtKB:A0AB32TYC7	InterPro	1572
UniProtKB:A0AB32TZB6	InterPro	1698
UniProtKB:A0AB32TZC9	InterPro	1711
UniProtKB:A0AB32TZD0	InterPro	1668
UniProtKB:A0AB32TZD1	InterPro	1641
UniProtKB:A0AB32TZE3	InterPro	1601
UniProtKB:A0AB32TZE5	InterPro	1642
UniProtKB:A0AB32TZE7	InterPro	1572
UniProtKB:A0AB32TZF8	InterPro	1591
UniProtKB:A0AB32TZF9	InterPro	1553
UniProtKB:A0AB32U0I5	InterPro	1710
UniProtKB:A0AB32U0J7	InterPro	1642
UniProtKB:A0AB32U0L3	InterPro	1573

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	madd-201 (1) Ensembl	Ensembl	5,205 nt	Select Tool ZFIN BLAST
mRNA	madd-202 (1) Ensembl	Ensembl	450 nt	Select Tool ZFIN BLAST
mRNA	madd-205 (1) Ensembl	Ensembl	6,979 nt	Select Tool ZFIN BLAST
mRNA	madd-206 (1) Ensembl	Ensembl	182 nt	Select Tool ZFIN BLAST
mRNA	madd-208 (1) Ensembl	Ensembl	4,981 nt	Select Tool ZFIN BLAST
ncRNA	madd-004 (1) Ensembl	Ensembl	538 nt	Select Tool ZFIN BLAST
ncRNA	madd-005 (1) Ensembl	Ensembl	480 nt	Select Tool ZFIN BLAST
ncRNA	madd-006 (1) Ensembl	Ensembl	539 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations