ZFIN is now using GRCz12tu for Genomic Data
Gene
atl1
- ID
- ZDB-GENE-030131-8003
- Name
- atlastin GTPase 1
- Symbol
- atl1 Nomenclature History
- Previous Names
-
- fj46c01
- spg3a (1)
- wu:fj46c01
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within determination of dorsal identity and negative regulation of BMP signaling pathway. Located in late endosome. Is expressed in brain; primary motor neurons; skeletal muscle; and spinal cord neural tube. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Orthologous to human ATL1 (atlastin GTPase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary sensory neuropathy type 1D | Alliance | Neuropathy, hereditary sensory, type ID | 613708 |
| hereditary spastic paraplegia 3A | Alliance | Spastic paraplegia 3A, autosomal dominant | 182600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR015894 | Guanylate-binding protein, N-terminal |
| Domain | IPR030386 | GB1/RHD3-type guanine nucleotide-binding (G) domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036543 | Guanylate-binding protein, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | GB1/RHD3-type guanine nucleotide-binding (G) domain | Guanylate-binding protein, C-terminal domain superfamily | Guanylate-binding protein, N-terminal | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:B8A6H1 | InterPro | 554 | ||||
| UniProtKB:E9QGX9 | InterPro | 559 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atl1 | polyclonal | IgG | Goat |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers