Gene
il12bb
- ID
- ZDB-GENE-030131-7937
- Name
- interleukin 12B, b
- Symbol
- il12bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Predicted to be located in extracellular space. Is expressed in digestive system; gill; immune system; and muscle. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa23998 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 29 | Alliance | Immunodeficiency 29, mycobacteriosis | 614890 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0AB32TB47 | InterPro | 305 |
| UniProtKB:A0AB32TI82 | InterPro | 271 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il12bb-201
(1)
|
Ensembl | 920 nt | ||
| mRNA |
il12bb-202
(1)
|
Ensembl | 1,609 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-213N8 | ||
| Encodes | EST | fj42c06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068216128 (1) | 1126 nt | ||
| Genomic | GenBank:CT998559 (1) | 236820 nt | ||
| Polypeptide | UniProtKB:A0AB32TB47 (1) | 305 aa |
- Apaydin, D.C., Zakarauskas-Seth, B.I., Carnevale, L., Apaydin, O., Perrotta, M., Carnevale, R., Kotini, M.P., Kotlar-Goldaper, I., Belting, H.G., Carnevale, D., Filosa, A., Sawamiphak, S. (2022) Interferon-γ drives macrophage reprogramming, cerebrovascular remodeling, and cognitive dysfunction in a zebrafish and a mouse model of ion imbalance and pressure overload. Cardiovascular research. 119(5):1234-1249
- Wang, X., Li, W., Jiang, H., Ma, C., Huang, M., Wei, X., Wang, W., Jing, L. (2022) Zebrafish Xenograft Model for Studying Pancreatic Cancer-Instructed Innate Immune Microenvironment. International Journal of Molecular Sciences. 23(12)
- Qiu, W., Chen, B., Greer, J., Magnuson, J., Xiong, Y., Zhong, H., Andrzejczyk, N.E., Zheng, C., Schlenk, D. (2019) Transcriptomic responses of Bisphenol S predict involvement of immune function in the cardiotoxicity of early life stage zebrafish (Danio rerio). Environmental science & technology. 54(5):2869-2877
- Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832
- Yang, D., Zheng, X., Chen, S., Wang, Z., Xu, W., Tan, J., Hu, T., Hou, M., Wang, W., Gu, Z., Wang, Q., Zhang, R., Zhang, Y., Liu, Q. (2018) Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Nature communications. 9:3052
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Liu, X., Wu, H., Liu, Q., Wang, Q., Xiao, J., Chang, X., Zhang, Y. (2015) Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish & shellfish immunology. 45(2):342-5
- Holt, A., Mitra, S., van der Sar, A.M., Alnabulsi, A., Secombes, C.J., and Bird, S. (2011) Discovery of zebrafish (Danio rerio) interleukin-23 alpha (IL-23α) chain, a subunit important for the formation of IL-23, a cytokine involved in the development of Th17 cells and inflammation. Molecular immunology. 48(8):981-991
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
- Nascimento, D.S., do Vale, A., Tomás, A.M., Zou, J., Secombes, C.J., and dos Santos, N.M. (2007) Cloning, promoter analysis and expression in response to bacterial exposure of sea bass (Dicentrarchus labrax L.) interleukin-12 p40 and p35 subunits. Molecular immunology. 44(9):2277-2291
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